Endocrine (2018) 62:271–273 https://doi.org/10.1007/s12020-018-1632-2 EDITORIAL Primary hyperparathyroidism in prostate cancer: guilty or not guilty? 1 2 3 ● ● G. Mazziotti S. Frara A. Mosca Received: 9 March 2018 / Accepted: 9 May 2018 / Published online: 30 May 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Skeletal health is a clinically relevant issue in patients with probability to express PHPT. Notably, PC with the best prostate cancer (PC) [1–3]. Bone is the most common site of prognostic characteristics was considered “protective for PC cell migration with up to 90% of patients with advanced PHPT” by Minisola et al. . disease having bone metastases  with potential negative The pathophysiological determinants of these associa- impact on quality of life and survival . Since the ﬁrst tions were not clariﬁed in this study, but the authors description of the “seed and soil” hypothesis by Stephan hypothesized that in patients with higher PC activity/bio- Paget in 1889 , several cellular signaling pathways, logical aggressiveness, as assessed by high GS, osteo- cytokines, chemokines, and adhesion molecules have been blastic bone metastases may favor the development of identiﬁed as players of cross-talking between PC cells and PHPT by decreasing serum
Endocrine – Springer Journals
Published: May 30, 2018
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