Purpose Patients receiving platinum-based chemotherapy are in patients with lung cancer receiving platinum-based chemo- at high risk of chemotherapy-induced nausea and vomiting therapy, across the acute, delayed, and overall phases and (CINV), a distressing side effect of treatment. This post-hoc throughout multiple cycles. As a highly effective oral combi- subgroup analysis of two pivotal trials evaluated the efficacy nation antiemetic agent administered as a single dose once per of NEPA in preventing CINV in subsets of patients with lung cycle, NEPA may offer a convenient, simplified prophylactic cancer who received cisplatin or carboplatin. antiemetic. Methods In each study, the efficacy endpoints complete re- . . . sponse (CR; defined as no emetic episodes and no rescue Keywords Lung cancer Cisplatin Carboplatin medication) and no significant nausea (NSN; defined as a Chemotherapy-induced nausea and vomiting (CINV) NEPA score of < 25 mm on a visual analog scale of 0–100 mm) during the acute (0–24 h), delayed (25–120 h), and overall (0–120 h) phases post-chemotherapy in cycle 1 (study 1) Introduction and cycles 1–4 (study 2) were assessed. Safety was evaluated by recording treatment-emergent adverse events (AEs) and Lung cancer is the most common cancer worldwide, with treatment-related AEs. an estimated
Supportive Care in Cancer – Springer Journals
Published: Oct 28, 2017
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