Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors

Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central... The human neurotropic JC virus (JCV) is of significant interest due to its experimental neuro- oncogenic potential. In clinical samples from human central nervous system (CNS) tumors, detection of JCV sequences suggests a possible association with CNS neoplasms, but the results are discrepant worldwide. To assess the prevalence of JCV sequences in Iranian patients with primary and metastatic CNS malignancies, a total of 58 fresh CNS tumors were examined by quantitative real-time PCR targeting the JCV large T antigen (LT-Ag) gene, and JCV DNA load was determined as viral copy number per cell. All patients were immunocompetent, and none of them had received immunosuppressive therapy before surgical operation. JC virus LT-Ag sequences were found in a total of 15 (25.9 %) out of the 58 tested samples. In primary CNS tumors, JCV sequences were identified more frequently in meningiomas (50.0 %) and schwannomas (35.7 %). In metastatic CNS tumors, JCV LT-Ag was identified in one case with brain adenocarcinoma originating from lung cancer. No statistically significant association between JCV positivity and various types of CNS malignancies was observed ( P = 0.565 ). The mean JCV LT-Ag copy number in 15 positive cases was 1.8 × 10 −4 ± 4.5 × 10 −4 copies per cell (range 1.0 × 10 −5 -1.78 × 10 −3 copies per cell). An inverse correlation between white blood cell (WBC) count and JCV copy number was observed, but this correlation was not statistically significant ( R = −0.198, P = 0.480 ). This study provides the first data on the prevalence of JCV in primary and metastatic CNS tumors from Iranian patients. Archives of Virology Springer Journals

Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors

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Springer Vienna
Copyright © 2015 by Springer-Verlag Wien
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
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