Background and purpose To test the hypothesis that the prev- in prevalence of DVA-associated cavernous malformations alence of cerebral cavernous malformation (CCM) associated among patients with DVAs. These findings suggest that with developmental venous anomalies (DVAs) increases with DVA-associated cavernous malformations are acquired age, we studied the age-related prevalence of DVA-associated lesions. CCM among patients with DVAs. . . Materials and methods Patients with DVAs on contrast- Keywords Cavernous malformation Natural history . . enhanced MRI exams performed over a 2-year period were Developmental venous anomaly De novo Vascular included in this study. A single neuroradiologist reviewed all malformation imaging exams for the presence of CCMs. Baseline demo- graphic data collected included age, gender, presence of CNS neoplasm, history of cranial radiation, and history of Introduction seizure. Patients were divided into age groups based on de- cade of life. Cochran-Armitage trend tests were performed to The pathogenesis and timing of cerebral cavernous malforma- determine if increasing age was associated with CCM tion (CCM) development among patients with developmental prevalence. venous anomalies (DVAs) is unclear. Interestingly, up to 25% Results A total of 1689 patients with DVAs identified on of CCMs are associated with DVAs [1, 2] on standard se-
Child's Nervous System – Springer Journals
Published: Jun 22, 2017
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