Preparing pathology for the molecular era

Preparing pathology for the molecular era Virchows Arch (2017) 471:137–140 DOI 10.1007/s00428-017-2198-8 EDITORIAL 1 2 Fred T. Bosman & George J. Netto Published online: 17 July 2017 Springer-Verlag GmbH Deutschland 2017 Pathology as a clinical diagnostic discipline is not quite being papers discussing general issues and closes with papers re-invented, but there is no doubt that if Rudolph Virchow reviewing the current status of the role of pathology in select- could have made a Bback to the future^ maneuver, he would ed areas of molecular medicine. have been highly impressed. His paradigm of Bcellular^ pa- The opening paper by Kaul (DOI 10.1007/s00428-017- thology being replaced by that of Bmolecular^ pathology! Is 2141-z) concludes that molecular (Bgenomic^)analysesare this change in focus really a paradigm shift? Not necessarily. becoming standard in the assessment of the pathology of One way to think about this is that three decades ago diagnos- cancer. Methods and equipment remain in rapid tic histopathology had as endpoint what one could do with development, which continuously expands areas of classical morphology: reading patterns of gene expression application. Standardization and quality assurance are the without knowing which genes were involved. What makes responsibilities of pathologists and indeed consensus today’s pathology so exciting is that gradually http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virchows Archiv Springer Journals

Preparing pathology for the molecular era

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Deutschland
Subject
Medicine & Public Health; Pathology
ISSN
0945-6317
eISSN
1432-2307
D.O.I.
10.1007/s00428-017-2198-8
Publisher site
See Article on Publisher Site

Abstract

Virchows Arch (2017) 471:137–140 DOI 10.1007/s00428-017-2198-8 EDITORIAL 1 2 Fred T. Bosman & George J. Netto Published online: 17 July 2017 Springer-Verlag GmbH Deutschland 2017 Pathology as a clinical diagnostic discipline is not quite being papers discussing general issues and closes with papers re-invented, but there is no doubt that if Rudolph Virchow reviewing the current status of the role of pathology in select- could have made a Bback to the future^ maneuver, he would ed areas of molecular medicine. have been highly impressed. His paradigm of Bcellular^ pa- The opening paper by Kaul (DOI 10.1007/s00428-017- thology being replaced by that of Bmolecular^ pathology! Is 2141-z) concludes that molecular (Bgenomic^)analysesare this change in focus really a paradigm shift? Not necessarily. becoming standard in the assessment of the pathology of One way to think about this is that three decades ago diagnos- cancer. Methods and equipment remain in rapid tic histopathology had as endpoint what one could do with development, which continuously expands areas of classical morphology: reading patterns of gene expression application. Standardization and quality assurance are the without knowing which genes were involved. What makes responsibilities of pathologists and indeed consensus today’s pathology so exciting is that gradually

Journal

Virchows ArchivSpringer Journals

Published: Jul 17, 2017

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