Preparation of immobilized hexamine on Fe3O4/SiO2 core/shell nanoparticles: a novel catalyst for solvent-free synthesis of bis(indolyl)methanes

Preparation of immobilized hexamine on Fe3O4/SiO2 core/shell nanoparticles: a novel catalyst for... Keywords Magnetically retrievable  Nano-hybrid  Bis(indolyl)methanes  Solvent- free  Silica  Hexamethylenetetramine & Issa Yavari yavarisa@modares.ac.ir Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran Chemistry Department, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran 123 8218 S. Kangari, I. Yavari Introduction Catalytic applications of magnetic nanoparticles (MNPs) have attracted increasing attention owing to their unique magnetic properties and easy separation from the reaction system by an external magnetic field rather than filtration or centrifugation [1–5]. However, MNPs without coating are often unstable and tend to aggregate during catalytic transformations, resulting in a remarkable drop of catalytic activity owing to the decrease of surface area. Thus, MNPs are modified with high surface coating materials. Silica is usually used as an important coating material because of its low cost, high surface area, and ease of modification with organic functional groups [6]. Recently, silica-coated MNPs have been used as appropriate supports for covalent bond formation with organic materials [7–9]. Indole and its derivatives are an important class of heterocyclic compounds in medicinal chemistry. In particular, bis(indolyl)methanes (BIMs) are active against human cancer cells [10–13]. The electrophilic substitution reaction of indoles with aldehydes affords the corresponding BIMs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Preparation of immobilized hexamine on Fe3O4/SiO2 core/shell nanoparticles: a novel catalyst for solvent-free synthesis of bis(indolyl)methanes

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2590-z
Publisher site
See Article on Publisher Site

Abstract

Keywords Magnetically retrievable  Nano-hybrid  Bis(indolyl)methanes  Solvent- free  Silica  Hexamethylenetetramine & Issa Yavari yavarisa@modares.ac.ir Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran Chemistry Department, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran 123 8218 S. Kangari, I. Yavari Introduction Catalytic applications of magnetic nanoparticles (MNPs) have attracted increasing attention owing to their unique magnetic properties and easy separation from the reaction system by an external magnetic field rather than filtration or centrifugation [1–5]. However, MNPs without coating are often unstable and tend to aggregate during catalytic transformations, resulting in a remarkable drop of catalytic activity owing to the decrease of surface area. Thus, MNPs are modified with high surface coating materials. Silica is usually used as an important coating material because of its low cost, high surface area, and ease of modification with organic functional groups [6]. Recently, silica-coated MNPs have been used as appropriate supports for covalent bond formation with organic materials [7–9]. Indole and its derivatives are an important class of heterocyclic compounds in medicinal chemistry. In particular, bis(indolyl)methanes (BIMs) are active against human cancer cells [10–13]. The electrophilic substitution reaction of indoles with aldehydes affords the corresponding BIMs.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 16, 2016

References

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