Keywords Magnetically retrievable Nano-hybrid Bis(indolyl)methanes Solvent- free Silica Hexamethylenetetramine & Issa Yavari firstname.lastname@example.org Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran Chemistry Department, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran 123 8218 S. Kangari, I. Yavari Introduction Catalytic applications of magnetic nanoparticles (MNPs) have attracted increasing attention owing to their unique magnetic properties and easy separation from the reaction system by an external magnetic ﬁeld rather than ﬁltration or centrifugation [1–5]. However, MNPs without coating are often unstable and tend to aggregate during catalytic transformations, resulting in a remarkable drop of catalytic activity owing to the decrease of surface area. Thus, MNPs are modiﬁed with high surface coating materials. Silica is usually used as an important coating material because of its low cost, high surface area, and ease of modiﬁcation with organic functional groups . Recently, silica-coated MNPs have been used as appropriate supports for covalent bond formation with organic materials [7–9]. Indole and its derivatives are an important class of heterocyclic compounds in medicinal chemistry. In particular, bis(indolyl)methanes (BIMs) are active against human cancer cells [10–13]. The electrophilic substitution reaction of indoles with aldehydes affords the corresponding BIMs.
Research on Chemical Intermediates – Springer Journals
Published: Jun 16, 2016
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