International Orthopaedics (SICOT) (2017) 41:1899–1908 DOI 10.1007/s00264-017-3522-2 ORIGINAL PAPER Preparation of a biphase composite scaffold and its application in tissue engineering for femoral osteochondral defects in rabbits 1,2 2 2 2 1 Shi-qiang Ruan & Ling Yan & Jiang Deng & Wen-liang Huang & Dian-ming Jiang Received: 11 January 2017 /Accepted: 15 May 2017 /Published online: 14 June 2017 SICOT aisbl 2017 Abstract injury, mixing and filling function were exerted by the cell- Purpose Three-dimensional bioactive scaffolds are useful scaffold constructs (CSCs). Micro-CT scanning revealed both tools for stem cell implant in tissue-engineering. For chondral chondral and subchondral layers were repaired. Moreover, and subchondral repair, the chondroinductive and type I and II collagens were both expressed in the implanted osteoinductive property of a scaffold is a major challenge. CSCs. The scaffolds that aim to osteogenic differentiation have been Conclusions Chondral and subchondral repair can be well studied. However, cartilage cells can hardly be induced achieved using the biphase scaffold implant that permits both for osteogenesis, and monophase scaffolds cannot ideally re- chondrogenesis and osteogenesis from BMSCs. This ap- pair both cartilage and subchondral defects at the same time. proach has the potential to be clinically used for tissue engi-
International Orthopaedics – Springer Journals
Published: Jun 14, 2017
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