Preparation and performance valuation of high selective molecularly imprinted polymers for malachite green

Preparation and performance valuation of high selective molecularly imprinted polymers for... Molecular imprinting is a technology that facilitates the production of artificial receptors toward compounds of interest. In this study, we prepared a series of molecularly imprinted polymers (MIPs) by precipitation polymerization for the purpose of binding specifically to malachite green (MG). The presence of monomer–template solution complexes in non-covalent MIPs systems had been verified by UV-spectrometric detection and molecular dynamics simulations. The synthesized parameters were, respectively, optimized and the optimal conditions for the efficient adsorption property were as follows: template: MG, 1 mmol; functional monomer: methacrylic acid (MAA), 8 mmol; cross-linker: ethylene glycol dimethacryllate, 16 mmol; and porogen: acetonitrile, 30 mL. Fourier transform infrared spectroscopy and nitrogen adsorption experiments were used to characterize the MIPs. Scatchard analysis was used for estimation of the dissociation constants and maximum amounts of binding sites. The polymer based on MAA had two classes of heterogeneous binding sites characterized by two values of K D and B max: K D = 14.10 μmol L−1 and B max = 1.37 μmol g−1 for the higher affinity binding sites, and K D = 384.62 μmol L−1 and B max = 24.77 μmol g−1 for the lower affinity binding sites. The specificity of MIPs on SPE column was evaluated by rebinding the other structurally similar compounds. The results indicated that the imprinted polymers exhibited an excellent stereo-selectivity toward MG. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Preparation and performance valuation of high selective molecularly imprinted polymers for malachite green

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Publisher
Springer Netherlands
Copyright
Copyright © 2012 by Springer Science+Business Media B.V.
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-012-0759-7
Publisher site
See Article on Publisher Site

Abstract

Molecular imprinting is a technology that facilitates the production of artificial receptors toward compounds of interest. In this study, we prepared a series of molecularly imprinted polymers (MIPs) by precipitation polymerization for the purpose of binding specifically to malachite green (MG). The presence of monomer–template solution complexes in non-covalent MIPs systems had been verified by UV-spectrometric detection and molecular dynamics simulations. The synthesized parameters were, respectively, optimized and the optimal conditions for the efficient adsorption property were as follows: template: MG, 1 mmol; functional monomer: methacrylic acid (MAA), 8 mmol; cross-linker: ethylene glycol dimethacryllate, 16 mmol; and porogen: acetonitrile, 30 mL. Fourier transform infrared spectroscopy and nitrogen adsorption experiments were used to characterize the MIPs. Scatchard analysis was used for estimation of the dissociation constants and maximum amounts of binding sites. The polymer based on MAA had two classes of heterogeneous binding sites characterized by two values of K D and B max: K D = 14.10 μmol L−1 and B max = 1.37 μmol g−1 for the higher affinity binding sites, and K D = 384.62 μmol L−1 and B max = 24.77 μmol g−1 for the lower affinity binding sites. The specificity of MIPs on SPE column was evaluated by rebinding the other structurally similar compounds. The results indicated that the imprinted polymers exhibited an excellent stereo-selectivity toward MG.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Aug 28, 2012

References

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