Preoperative Watchful–Waiting Time and Surgical Outcome of Patients with Non-small Cell Lung Cancer Found by Chest Low-Dose CT Screening

Preoperative Watchful–Waiting Time and Surgical Outcome of Patients with Non-small Cell Lung... Backgrounds Chest low-dose CT screening (LDCTS) has been finding unprecedented numbers of peripheral non- small cell lung cancers (NSCLC) at an early stage and increased the number of patients with surgical indication. It is important to explore the influence of preoperative watchful–waiting time (WWT) on surgical outcomes. Objective is to clarify relationship between WWT and surgical outcomes of LDCTS-finding NSCLC from the view point of treatment delay. Methods Total 283 cases of NSCLC, found by LDCTS and consecutively resected, were surveyed for preoperative WWT and surgical outcomes. Validity of the present guideline for management of pulmonary nodules detected by LDCTS was verified whether WWT before surgery was suitable for eradication of NSCLC. Results The median value of WWT was 4.0 months in total, and the distribution of WWT exhibited long-tail-type pattern. That was 5.0 months in the group of pure ground-glass nodule (pGGN), 4.0 months in the group of part-solid nodule (PSN), and 1.7 months in the group of solid nodule (SON). During long-term postoperative observation time (median 79 months), 10-year progression-free survival rates were 100% in pGGN, 96% in PSN, and 72% in SON (P \ .0001). They decreased significantly depending on enlargement of size: 91% or higher http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Journal of Surgery Springer Journals

Preoperative Watchful–Waiting Time and Surgical Outcome of Patients with Non-small Cell Lung Cancer Found by Chest Low-Dose CT Screening

Download PDF
9 pages
Read Article

Loading next page...
 
/lp/springer_journal/preoperative-watchful-waiting-time-and-surgical-outcome-of-patients-oZzgto8VWB
Publisher
Springer Journals
Copyright
Copyright © 2018 by Société Internationale de Chirurgie
Subject
Medicine & Public Health; Surgery; Abdominal Surgery; Cardiac Surgery; General Surgery; Thoracic Surgery; Vascular Surgery
ISSN
0364-2313
eISSN
1432-2323
DOI
10.1007/s00268-017-4439-z
pmid
29492597
Publisher site
See Article on Publisher Site

Abstract

Backgrounds Chest low-dose CT screening (LDCTS) has been finding unprecedented numbers of peripheral non- small cell lung cancers (NSCLC) at an early stage and increased the number of patients with surgical indication. It is important to explore the influence of preoperative watchful–waiting time (WWT) on surgical outcomes. Objective is to clarify relationship between WWT and surgical outcomes of LDCTS-finding NSCLC from the view point of treatment delay. Methods Total 283 cases of NSCLC, found by LDCTS and consecutively resected, were surveyed for preoperative WWT and surgical outcomes. Validity of the present guideline for management of pulmonary nodules detected by LDCTS was verified whether WWT before surgery was suitable for eradication of NSCLC. Results The median value of WWT was 4.0 months in total, and the distribution of WWT exhibited long-tail-type pattern. That was 5.0 months in the group of pure ground-glass nodule (pGGN), 4.0 months in the group of part-solid nodule (PSN), and 1.7 months in the group of solid nodule (SON). During long-term postoperative observation time (median 79 months), 10-year progression-free survival rates were 100% in pGGN, 96% in PSN, and 72% in SON (P \ .0001). They decreased significantly depending on enlargement of size: 91% or higher

Journal

World Journal of Surgery – Springer Journals

Published: Feb 28, 2018

References

  • international early lung cancer action program investigators. Survival of patients with stage I lung cancer detected on CT screening
    Henschke, CI; Yankelevitz, DF; Libby, DM
  • Reduced lung-cancer mortality with low-dose computed tomographic screening
    Aberle, DR; Adams, AM; Berg, CD
  • Sublobar resection is equivalent to lobectomy for clinical stage 1A lung cancer in solid nodules
    Altorki, NK; Yip, R; Hanaoka, T
  • Different efficacy of CT screening for lung cancer according to histological type: analysis of Japanese-smoker cases detected using a low-dose CT screen
    Kondo, R; Yoshida, K; Kawakami, S
  • Growth rate of small lung cancers detected on mass CT screening
    Hasegawa, M; Sone, S; Takashima, S
  • NLST overdiagnosis manuscript writing team. Overdiagnosis in low-dose computed tomography screening for lung cancer
    Patz, EF; Pinsky, P; Gatsonis, C
  • HRCT features of small peripheral lung carcinomas detected in a low-dose CT screening program
    Sone, S; Matsumoto, T; Honda, T
  • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
    Travis, WD; Brambilla, E; Noguchi, M
  • Genomic landscape of atypical adenomatous hyperplasia reveals divergent modes to lung adenocarcinoma
    Sivakumar, S; San Lucas, FA; McDowell, TL
  • Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: histopathologic features and their prognostic implications
    Vazquez, M; Carter, D; Brambilla, E
  • Volume-doubling time of pulmonary nodules with ground glass opacity at multidetector CT: assessment with computer-aided three-dimensional volumetry
    Oda, S; Awai, K; Murao, K
  • Radiographically determined noninvasive adenocarcinoma of the lung: survival outcomes of Japan Clinical Oncology Group 0201
    Asamura, H; Hishida, T; Suzuki, K
  • Correlation between whole tumor size and solid component size on high-resolution computed tomography in the prediction of the degree of pathologic malignancy and the prognostic outcome in primary lung adenocarcinoma
    Saji, H; Matsubayashi, J; Akata, S
  • Pulmonary adenocarcinomas appearing as part-solid ground-glass nodules: is measuring solid component size a better prognostic indicator?
    Hwang, EJ; Park, CM; Ryu, Y
  • Risk factors for recurrence after sublobar resection in patients with small (2 cm or less) non-small cell lung cancer presenting as a solid-predominant tumor on chest computed tomography
    Moon, Y; Sung, SW; Moon, SW
  • Does ground glass opacity-dominant feature have a prognostic significance even in clinical T2aN0M0 lung adenocarcinoma?
    Nakamura, S; Fukui, T; Kawaguchi, K
  • Association between high-resolution computed tomography findings and the IASLC/ATS/ERS classification of small lung adenocarcinomas in Japanese patients
    Kudo, Y; Matsubayashi, J; Saji, H
  • Sublobar resection for lung adenocarcinoma meeting node-negative criteria on preoperative imaging
    Tsutani, Y; Miyata, Y; Nakayama, H
  • Outcomes of lung cancers manifesting as nonsolid nodules
    Yip, R; Wolf, A; Tam, K
  • Solitary pure ground-glass nodules 5 mm or smaller: frequency of growth
    Kakinuma, R; Muramatsu, Y; Kusumoto, M
  • CT screening for lung cancer: part-solid nodules in baseline and annual repeat rounds
    Henschke, CI; Yip, R; Smith, JP
  • Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi type B, in three patients
    Yoshida, J; Ishii, G; Yokose, T
  • Thin-section computed tomography findings of lung adenocarcinoma with inherent metastatic potential
    Suzuki, S; Aokage, K; Yoshida, J
  • What are the radiologic findings predictive of indolent lung adenocarcinoma?
    Mimae, T; Miyata, Y; Tsutani, Y
  • Prognostic importance of volumetric measurements in stage I lung adenocarcinoma
    Yanagawa, M; Tanaka, Y; Leung, AN

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial