Ann Surg Oncol (2017) 24:2518–2525 DOI 10.1245/s10434-017-5872-9 OR IG INA L A R TIC L E – BREA S T O NC OLOG Y Preoperative Prediction of Node-Negative Disease After Neoadjuvant Chemotherapy in Patients Presenting with Node- Negative or Node-Positive Breast Cancer 1,2 3 3 Brittany L. Murphy, MD, MS , Tanya L. Hoskin, MS , Courtney Day N. (Heins), BS , Elizabeth B. Habermann, 1,2,3 1 PhD, MPH , and Judy C. Boughey, MD 1 2 Department of Surgery, Mayo Clinic, Rochester, MN; The Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN; Department of Health Science Research, Mayo Clinic, Rochester, MN ABSTRACT Results. Of 16,153 NCDB patients, 6659 (41%) were cN0 Background. Axillary node status after neoadjuvant and 9494 (59%) were cN?. Factors associated with chemotherapy (NAC) inﬂuences the axillary surgical pathologic nodal status and included in the models were staging procedure as well as recommendations regarding patient age, tumor grade, biologic subtype, histology, reconstruction and radiation. clinical tumor category, and, in cN? patients only, clinical Objective. Our aim was to construct a clinical preopera- nodal category. The validation dataset included 194 cN0 tive prediction model to identify
Annals of Surgical Oncology – Springer Journals
Published: May 8, 2017
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