Preneural transmitters as regulators of embryogenesis. Current state of problem

Preneural transmitters as regulators of embryogenesis. Current state of problem Our knowledge about the preneural neurotransmitter systems and their functions were based on the old pharmacological and biochemical data that have recently been confirmed and substantially supplemented. Specific components of the preneural serotoninergic and endocannabinoid systems were identified in developing echinoderm embryos using immunocytochemistry, Western immunoelectroblotting, and HPLC-mass spectroscopy. These data were corroborated by the results of pharmacological experiments: it was found that some ligands of serotonin receptors, as well as the agonist of cannabinoid receptors anandamide induced the appearance of abnormal embryonic phenotypes, whose expression depended on the ligand-teratogen concentration. Their appearance was prevented, correspondingly, by serotonin and its lipophilic (or hydrophilic) analogs and antagonists of cannabinoid (CB1CB2)-receptors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Preneural transmitters as regulators of embryogenesis. Current state of problem

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Publisher
Springer Journals
Copyright
Copyright © 2007 by Pleiades Publishing, Inc.
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360407040042
Publisher site
See Article on Publisher Site

Abstract

Our knowledge about the preneural neurotransmitter systems and their functions were based on the old pharmacological and biochemical data that have recently been confirmed and substantially supplemented. Specific components of the preneural serotoninergic and endocannabinoid systems were identified in developing echinoderm embryos using immunocytochemistry, Western immunoelectroblotting, and HPLC-mass spectroscopy. These data were corroborated by the results of pharmacological experiments: it was found that some ligands of serotonin receptors, as well as the agonist of cannabinoid receptors anandamide induced the appearance of abnormal embryonic phenotypes, whose expression depended on the ligand-teratogen concentration. Their appearance was prevented, correspondingly, by serotonin and its lipophilic (or hydrophilic) analogs and antagonists of cannabinoid (CB1CB2)-receptors.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Aug 10, 2007

References

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