Psychopharmacology (2018) 235:651–661 https://doi.org/10.1007/s00213-017-4780-9 ORIGINAL INVESTIGATION Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood 1 1 1 1 Britta Hahn & Carolyn H. Reneski & Ana Pocivavsek & Robert Schwarcz Received: 13 July 2017 /Accepted: 1 November 2017 /Published online: 11 November 2017 Springer-Verlag GmbH Germany, part of Springer Nature 2017 Abstract responses. This pattern cannot be explained by differences in Rationale Elevated brain kynurenic acid (KYNA) levels are response rate and is indicative of a narrowed attentional focus. implicated in the pathology and neurodevelopmental patho- Conclusions The findings suggest a potential etiology of genesis of schizophrenia. In rats, embryonic treatment with broad monitoring deficits in schizophrenia, which may con- kynurenine (EKyn) causes elevated brain KYNA levels in stitute a core cognitive deficit. adulthood and cognitive deficits reminiscent of schizophrenia. . . . Objectives Growing evidence suggests that people with Keywords Kynurenic acid Prenatal Attention Broad schizophrenia have a narrowed attentional focus, and we monitoring 5-Choice serial reaction time aimed at establishing whether these abnormalities may be re- lated to KYNA dysregulation. Methods To test whether EKyn rats display broad monitoring Introduction deficits, kynurenine was added to the chow of pregnant Wistar dams on embryonic
Psychopharmacology – Springer Journals
Published: Nov 11, 2017
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