Graefes Arch Clin Exp Ophthalmol (2017) 255:1593–1604 DOI 10.1007/s00417-017-3695-9 BASIC SCIENCE Preliminary study of the safety and efficacy of medium-chain triglycerides for use as an intraocular tamponading agent in minipigs 1,2,3 3,4 1 5 Vincent J. Soler & Camille Laurent & Frédéric Sakr & Alain Regnier & 2,3 6 6 5 Cyrielle Tricoire & Olivier Cases & Renata Kozyraki & Jean-Yves Douet & Véronique Pagot-Mathis Received: 17 January 2017 /Revised: 24 April 2017 /Accepted: 9 May 2017 /Published online: 25 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract day 90. Pigs were sacrificed on day 45 (Group A) or 120 Purpose To date, only silicone oils and gases have the appro- (Group B). Eyes were examined on days 1, 5, 15, and 45 in priate characteristics for use in vitreo-retinal surgery as vitre- both groups and on days 90 and 120 in Group B. In Group B ous substitutes with intraocular tamponading properties. This only, we performed bilateral electroretinography examina- preliminary study evaluated the safety and efficacy of tions on days 1 and 120, and histological examinations of medium-chain triglycerides (MCTs) for use as a tamponading MCTs and controlateral eyes were performed after sacrifice. agent in minipigs. Results In Group
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: May 25, 2017
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