Preface Cancer Metastasis Rev (2017) 36:193–194 DOI 10.1007/s10555-017-9680-2 David Menter Published online: 5 July 2017 Springer Science+Business Media, LLC 2017 Welcome to this timely special Cancer and Metastasis modulation, along with cancer progression and metastasis. Reviews issue on the small, often unheeded, but mighty plate- So, small and definitely yes, they are mighty. let. Small yes, but mighty you say? Well, they do not have This issue begins with an elegant overview of some nuclei and the human platelets are 2–3 μm in size. This makes important normal platelet properties and functions authored by Dr. Hollinstat. The second chapter authored them difficult to distinguish on pathologic review when com- pared to nucleated cells that are morphologically easier to by Drs. Menter, Kopetz, Hawk, Sood, Loree, Gresele, track and generally approach 10–30 μm in size. Ironically, andHonnexamines BPlatelets as First Responders,^ and the stage II megakaryocyte found in the bone marrow ranges we hope you agree that this is an appropriate moniker from 20 to 80 μm and is one of the largest cells in the human that adds to the notion of platelets being, mighty.Our body, thus they are of mighty lineage. Particularly since, the third entry by Drs. Coupland, Cancer and Metastasis Reviews Springer Journals

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Biomedicine; Cancer Research; Oncology; Biomedicine, general
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