Prednisone

Prednisone Reactions 1704, p320 - 2 Jun 2018 Steroid dementia syndrome : case report An 87-year-old man developed steroid dementia syndrome during treatment with prednisone [dosage and route not stated]. The man’s medical history was significant for hypertension, macular degeneration, depression. He was referred to geriatrics for memory concerns. He reported of difficulty in doing all his activities independently and his wife had to help him manage his medications, poor sleep, trouble remembering friend’s names and recent conversations. He was diagnosed with polymyalgia rheumatica and was started on a prednisone taper one month before decline in his condition. On the St. Louis University Mental Status (SLUMS) Exam, his score was 16/30. He was diagnosed with likely moderate dementia, either Alzheimer’s or vascular. Three months later, at a follow-up, the man’s rheumatologist had completely tapered off his steroids for four weeks. He and his wife reported of significant improvement in his sleep, memory and function and managed his medication. On a repeat SLUMS exam, his score was 24/30 along with improved parameters of clock draw and story recall. In view of a significant cognitive recovery following discontinuation of prednisone, a diagnosis of dementia was considered unlikely. He was diagnosed with reversible steroid related cognitive impairment persistent with steroid dementia syndrome [time to reaction onset not stated]. Author comment: "[T]he patient was thought to be more likely experiencing a reversible steroid related cognitive impairment consistent with [steroid dementia syndrome]." "Steroid dementia syndrome (SDS) . . . patients taking steroids who develop deficits mimicking symptoms of dementia and is frequently reversible after steroid discontinuation. " Stol I, et al. Corticosteroids causing dementia-like cognitive changes. Journal of the American Geriatrics Society 66 (Suppl. 2): S99-S100 abstr. B18, Apr 2018. Available from: URL: http://doi.org/10.1111/jgs.15376 [abstract] - USA 803323546 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Prednisone

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46963-0
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p320 - 2 Jun 2018 Steroid dementia syndrome : case report An 87-year-old man developed steroid dementia syndrome during treatment with prednisone [dosage and route not stated]. The man’s medical history was significant for hypertension, macular degeneration, depression. He was referred to geriatrics for memory concerns. He reported of difficulty in doing all his activities independently and his wife had to help him manage his medications, poor sleep, trouble remembering friend’s names and recent conversations. He was diagnosed with polymyalgia rheumatica and was started on a prednisone taper one month before decline in his condition. On the St. Louis University Mental Status (SLUMS) Exam, his score was 16/30. He was diagnosed with likely moderate dementia, either Alzheimer’s or vascular. Three months later, at a follow-up, the man’s rheumatologist had completely tapered off his steroids for four weeks. He and his wife reported of significant improvement in his sleep, memory and function and managed his medication. On a repeat SLUMS exam, his score was 24/30 along with improved parameters of clock draw and story recall. In view of a significant cognitive recovery following discontinuation of prednisone, a diagnosis of dementia was considered unlikely. He was diagnosed with reversible steroid related cognitive impairment persistent with steroid dementia syndrome [time to reaction onset not stated]. Author comment: "[T]he patient was thought to be more likely experiencing a reversible steroid related cognitive impairment consistent with [steroid dementia syndrome]." "Steroid dementia syndrome (SDS) . . . patients taking steroids who develop deficits mimicking symptoms of dementia and is frequently reversible after steroid discontinuation. " Stol I, et al. Corticosteroids causing dementia-like cognitive changes. Journal of the American Geriatrics Society 66 (Suppl. 2): S99-S100 abstr. B18, Apr 2018. Available from: URL: http://doi.org/10.1111/jgs.15376 [abstract] - USA 803323546 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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