Predictors of oxygenation impairment in medical treatment for type B acute aortic dissection

Predictors of oxygenation impairment in medical treatment for type B acute aortic dissection Lung oxygenation impairment often occurs in patients with type B acute aortic dissection (AAD), necessitating mechani- cal ventilation. Patients receiving mechanical ventilation are at risk of complications, so a low-oxygen condition requiring mechanical ventilation should be avoided. We explored the predictors of oxygenation impairment. We enrolled 46 patients with type B AAD who had been medically treated and underwent computed tomography. Blood was sampled to measure markers of inflammation, such as the C-reactive protein (CRP) levels and white blood cell count. The arterial partial pressure of oxygen/fraction of inspired oxygen ratio (PaO /FiO ) was calculated to quantify the severity of respiratory failure. Spear- 2 2 man’s rank correlation analysis revealed that the minimum P aO /FiO ratio was significantly correlated with gender, age, and 2 2 current smoker, and the peak CRP, body temperature, and D-dimer values. A multivariate regression analysis revealed that younger age, male sex, and the peak CRP level were significant predictors of the minimum P aO /FiO ratio (P = 0.01, 0.035 2 2 and 0.005, respectively). A covariance structure analysis showed that a younger age and the peak CRP level were significant predictors of oxygenation impairment in type B AAD. Oxygenation impairment in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heart and Vessels Springer Journals

Predictors of oxygenation impairment in medical treatment for type B acute aortic dissection

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Japan KK, part of Springer Nature
Subject
Medicine & Public Health; Cardiology; Cardiac Surgery; Vascular Surgery; Biomedical Engineering
ISSN
0910-8327
eISSN
1615-2573
D.O.I.
10.1007/s00380-018-1199-0
Publisher site
See Article on Publisher Site

Abstract

Lung oxygenation impairment often occurs in patients with type B acute aortic dissection (AAD), necessitating mechani- cal ventilation. Patients receiving mechanical ventilation are at risk of complications, so a low-oxygen condition requiring mechanical ventilation should be avoided. We explored the predictors of oxygenation impairment. We enrolled 46 patients with type B AAD who had been medically treated and underwent computed tomography. Blood was sampled to measure markers of inflammation, such as the C-reactive protein (CRP) levels and white blood cell count. The arterial partial pressure of oxygen/fraction of inspired oxygen ratio (PaO /FiO ) was calculated to quantify the severity of respiratory failure. Spear- 2 2 man’s rank correlation analysis revealed that the minimum P aO /FiO ratio was significantly correlated with gender, age, and 2 2 current smoker, and the peak CRP, body temperature, and D-dimer values. A multivariate regression analysis revealed that younger age, male sex, and the peak CRP level were significant predictors of the minimum P aO /FiO ratio (P = 0.01, 0.035 2 2 and 0.005, respectively). A covariance structure analysis showed that a younger age and the peak CRP level were significant predictors of oxygenation impairment in type B AAD. Oxygenation impairment in

Journal

Heart and Vessels – Springer Journals

Published: Jun 4, 2018

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