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Predictors of lymph node metastasis in patients with gastrointestinal stromal tumors (GISTs)

Predictors of lymph node metastasis in patients with gastrointestinal stromal tumors (GISTs) Background Lymph node metastasis is not common among patients with gastrointestinal stromal tumors (GISTs) and its prog- nostic value is controversial. The purposes of this study are to identify predictors of lymph node metastasis and determine its prognostic associations. Methods A retrospective analysis of the surveillance, epidemiology and end results (SEER) database was performed. Patients with GISTs that underwent surgery and pathologic nodal staging were identified. Logistic regression and Cox regression were performed to identify independent predictors and prognostic factors, respectively. Results Of 1430 patients (age: 61.5 ± 14.5 years, 52% males), 140 (9.8%) had lymph node metastasis. On multivariable analysis, distant metastasis was the only independent predictor of lymph node metastasis (OR 4.95, 95% CI: 2.43–10.08, p < 0.001). In the entire cohort, lymph node metastasis did not reflect a worse overall survival (OS, HR 1.12, 95% CI: 0.49–2.58, p =0.794) or disease-specific survival (DSS, HR 0.95, 95% CI: 0.31–2.88, p = 0.924), but was an independent predictor of worse OS in 51 patients (25.4% of 201 patients) who presented with both lymph node metastasis and synchronous distant metastasis (HR 2, 95% CI: 1.25–3.21, p = 0.004). Lymph node metastasis was also independently associated with worse survival among http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Langenbeck's Archives of Surgery Springer Journals

Predictors of lymph node metastasis in patients with gastrointestinal stromal tumors (GISTs)

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References (26)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; General Surgery; Abdominal Surgery; Cardiac Surgery; Thoracic Surgery; Traumatic Surgery; Vascular Surgery
ISSN
1435-2443
eISSN
1435-2451
DOI
10.1007/s00423-018-1683-0
Publisher site
See Article on Publisher Site

Abstract

Background Lymph node metastasis is not common among patients with gastrointestinal stromal tumors (GISTs) and its prog- nostic value is controversial. The purposes of this study are to identify predictors of lymph node metastasis and determine its prognostic associations. Methods A retrospective analysis of the surveillance, epidemiology and end results (SEER) database was performed. Patients with GISTs that underwent surgery and pathologic nodal staging were identified. Logistic regression and Cox regression were performed to identify independent predictors and prognostic factors, respectively. Results Of 1430 patients (age: 61.5 ± 14.5 years, 52% males), 140 (9.8%) had lymph node metastasis. On multivariable analysis, distant metastasis was the only independent predictor of lymph node metastasis (OR 4.95, 95% CI: 2.43–10.08, p < 0.001). In the entire cohort, lymph node metastasis did not reflect a worse overall survival (OS, HR 1.12, 95% CI: 0.49–2.58, p =0.794) or disease-specific survival (DSS, HR 0.95, 95% CI: 0.31–2.88, p = 0.924), but was an independent predictor of worse OS in 51 patients (25.4% of 201 patients) who presented with both lymph node metastasis and synchronous distant metastasis (HR 2, 95% CI: 1.25–3.21, p = 0.004). Lymph node metastasis was also independently associated with worse survival among

Journal

Langenbeck's Archives of Surgery – Springer Journals

Published: May 31, 2018

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