Investigational New Drugs https://doi.org/10.1007/s10637-018-0618-5 PRECLINICAL STUDIES Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR -antibody) against human breast cancer cells 1 1 Shujun Xiao & Jian Yang Received: 8 May 2018 /Accepted: 25 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Summary Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite, which regulates a broad range of physiological and pathophysiological processes. The signaling of S1P via its cell surface receptor S1PR has been identified to play an important role in carcinogenesis, cancer growth and survival, and tumor metastasis. In this study, we evaluated whether a monoclonal antibody against S1PR (S1PR -antibody) could impose any effect on cell growth of human breast cancer SK-BR-3 and MDA- 1 1 MB-231 cells. The S1PR -antibody exhibited cytostatic effect against both cell lines at the concentration of 4000 ng/mL. Co- administration of 4000 ng/mL of the S1PR -antibody not only potentiated the cytotoxicity of carboplatin towards the MDA-MB- 231 cells but also increased the anti-proliferative effect of S1P towards the SK-BR-3 cells. Furthermore, we showed that co- administration of S1P did not sensitize the SK-BR-3 and MDA-MB-231 cells towards carboplatin. . . . . Keywords S1PR -antibody Sphingosine-1-phosphate
Investigational New Drugs – Springer Journals
Published: Jun 2, 2018
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