Preclinical Models for Assessment of Antidepressant Abuse Potential

Preclinical Models for Assessment of Antidepressant Abuse Potential Curr Sex Health Rep (2017) 9:241–250 PRECLINICAL AND PSYCHOPHYSIOLOGY (F GUARRACI AND L MARSON, SECTION EDITORS) Preclinical Models for Assessment of Antidepressant Abuse Potential 1 2 M. F. Lazenka & B. A. Hutsell Published online: 17 October 2017 Springer Science+Business Media, LLC 2017 Abstract Introduction Purpose of Review This review considers the contribution of monoamine neurotransmitters to anhedonia, substance abuse, Depression has a worldwide prevalence of approximately 2– and sexual dysfunction and the relationship between antide- 5%. However, only half of patients in treatment remain symp- pressant efficacy and abuse liability. tom free and at least 10–20% of patients meet the criteria for Recent Findings The use of drugs with known abuse potential treatment-resistant depression [1]. Furthermore, sexual dys- to treat depression, the addition of psychostimulants with an- function (including desire, arousal, orgasm, and ejaculation) tidepressants, and the development of novel antidepressants is a common comorbidity with depression [2, 3]and, unfortu- with preclinical evidence for abuse liability have increased in nately, current antidepressants can exacerbate sexual dysfunc- recent years. This is in contrast to the general lack of abuse tion [4]. Therefore, new medications are clearly necessary. potential reported for traditional antidepressants such as selec- Development of pharmacotherapies Current Sexual Health Reports Springer Journals

Preclinical Models for Assessment of Antidepressant Abuse Potential

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Copyright © 2017 by Springer Science+Business Media, LLC
Medicine & Public Health; Urology; Endocrinology
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