Precision Medicine in the Management of Drug Allergy

Precision Medicine in the Management of Drug Allergy Purpose of study The term precision medicine has been developed in the last five or more years to describe the concept of treating patients individually based on a variety of factors. Precision medicine can be applied to the field of drug allergy where phenotypes, endotypes, and biomarkers have been defined. Recent findings Phenotypes of drug allergy can be based on (1) the mechanism of the underlying reaction; (2) the clinical presentation of the reaction; and (3) the timing of the reaction in regards to exposure to the drug. Endotypes of drug allergy can be defined based on mechanisms, pharmacologic processes, and human leukocyte antigen haplo- types. Lastly, biomarkers utilized in drug allergy include skin tests, specific IgE tests, basophil activation tests, cellular-based assays, mediator measurement, drug patch tests, and genotyping. The approach to penicillin allergy in recent years highlights the applica- tion of precision medicine in drug allergy. Introduction The term precision medicine has been developed in the technologies such as genomics, biobanking, and compu- last five or more years to describe the concept of treating tational biology have all been utilized. Furthermore, some patients individually based on a variety of factors. A similar authors have defined precision medicine http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Treatment Options in Allergy Springer Journals

Precision Medicine in the Management of Drug Allergy

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Allergology; General Practice / Family Medicine
eISSN
2196-3053
D.O.I.
10.1007/s40521-018-0159-3
Publisher site
See Article on Publisher Site

Abstract

Purpose of study The term precision medicine has been developed in the last five or more years to describe the concept of treating patients individually based on a variety of factors. Precision medicine can be applied to the field of drug allergy where phenotypes, endotypes, and biomarkers have been defined. Recent findings Phenotypes of drug allergy can be based on (1) the mechanism of the underlying reaction; (2) the clinical presentation of the reaction; and (3) the timing of the reaction in regards to exposure to the drug. Endotypes of drug allergy can be defined based on mechanisms, pharmacologic processes, and human leukocyte antigen haplo- types. Lastly, biomarkers utilized in drug allergy include skin tests, specific IgE tests, basophil activation tests, cellular-based assays, mediator measurement, drug patch tests, and genotyping. The approach to penicillin allergy in recent years highlights the applica- tion of precision medicine in drug allergy. Introduction The term precision medicine has been developed in the technologies such as genomics, biobanking, and compu- last five or more years to describe the concept of treating tational biology have all been utilized. Furthermore, some patients individually based on a variety of factors. A similar authors have defined precision medicine

Journal

Current Treatment Options in AllergySpringer Journals

Published: Feb 15, 2018

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