Eur J Nutr (2018) 57:107–117 https://doi.org/10.1007/s00394-016-1301-2 ORIGINAL CONTRIBUTION Pre‑pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion 1,3 2,3,4 2,5 Audrey J. Gaskins · Janet W. Rich‑Edwards · Paige L. Williams · 6 2,3,7,8 1,2,3 Thomas L. Toth · Stacey A. Missmer · Jorge E. Chavarro Received: 28 January 2016 / Accepted: 16 August 2016 / Published online: 29 August 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract consuming <50 mg/day (p trend = 0.05). Total coffee Purpose To investigate the relation between pre-pregnancy intake had a positive, linear association with SAB. Com- caffeine and caffeinated beverage intake and risk of sponta- pared to women with no pre-pregnancy coffee intake, neous abortion (SAB). women consuming ≥4 servings/day had a 20 % (6, 36 %) Methods Our prospective cohort study included 15,590 increased risk of SAB (p trend = 0.01). There was no dif- pregnancies from 11,072 women with no history of SAB in ference in the association between caffeinated and decaf- the Nurses’ Health Study II (1991–2009). Beverage intake feinated coffee and risk of SAB. Pre-pregnancy intake of was assessed every 4 years using a validated questionnaire. caffeinated tea, caffeinated soda, and decaffeinated soda Pregnancies were self-reported with
European Journal of Nutrition – Springer Journals
Published: Aug 29, 2016
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