Access the full text.
Sign up today, get DeepDyve free for 14 days.
Asymptomatic small vessel disease (SVD), including white matter hyperintensities (WMHIs), periventricular hyperintensities (PVHIs), silent stroke (SS), and cerebral microbleeds (CMBs), increases the risk of stroke. There are limited studies of SVD in subjects from the Middle East and Southeast Asia (SA). All patients admitted to stroke service between 2014 and 2015 were reviewed for presence of “pre-existing” SVD. Stroke mimics with no previous history of stroke were used as controls. There were 1727 patients admitted with stroke. Analysis was done on 988 subjects (914 strokes and 74 controls) who had MRI scan done. Pre-existing SVD was seen in 642 (64.9%) patients (WMHIs 19.6%, PVHIs 33.2%, SS 51.4%, and CMBs 22%). Silent strokes were significantly more common with ischemic stroke (IS) compared to intracranial hemorrhage (ICH) (62.0 vs 34.3%, p < 0.001). CMBs were more in ICH compared to IS (42.9 vs 23.1%, p < 0.001). The risk of developing CMBs among Far Eastern (FE) patients was 1.58 times more (p = 0.07), while 1.48 times more in Arabs (AR) (p = 0.026) compared to SA after adjusting for age. The risk of developing PVHIs was significantly higher in Arab compared to SA (odds ratio (OR) 1.43; p value = 0.021). Similarly, the risk of developing WMHIs was also significantly higher in AR patients (OR 1.6; p value = 0.009) compared to SA. The majority of ethnic AR, SA, and FE populations show pre-existing SVD on MRI. The advanced changes at a young age may be related to high prevalence of untreated risk factors and possibly as yet defined genetic and environmental factors.
Translational Stroke Research – Springer Journals
Published: Nov 3, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.