Eur J Plast Surg (2017) 40:263–264 DOI 10.1007/s00238-016-1258-7 SHORT COMMUNICATION 1 2 1 Krishna S. Vyas & Sibi Rajendran & Samir Mardini Received: 5 September 2016 /Accepted: 6 November 2016 /Published online: 1 December 2016 Springer-Verlag Berlin Heidelberg 2016 Although randomized controlled trials (RCTs) are necessary non-compliance in study protocols—features that are relevant to rigorously test and compare therapeutics, the information to real-world clinical settings [3–5]. yielded by these trials can sometimes be limited. RCTs operate RCTs are necessary to test an intervention against a clearly under ideal conditions with a highly defined patient popula- defined control group. PCTs are particularly useful for head- to-head comparisons of therapies, including alternative treat- tion in a strictly controlled environment and may not always produce information that can be directly translated to improve ments and non-pharmacologic therapies. RCTs and PCTs also clinical decisions for a heterogeneous population. Often, the differ in outcome measurement. RCTs measure objective and effectiveness of interventions implemented from RCTs is quantifiable data to determine safety and efficacy. PCTs mea- diminished from those observed in clinical practice. The goal sure a broad, diverse set of outcomes, many of which may be of the pragmatic clinical trial (PCT) is to
European Journal of Plastic Surgery – Springer Journals
Published: Dec 1, 2016
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