Pragmatic clinical trials: translating research into practice

Pragmatic clinical trials: translating research into practice Eur J Plast Surg (2017) 40:263–264 DOI 10.1007/s00238-016-1258-7 SHORT COMMUNICATION 1 2 1 Krishna S. Vyas & Sibi Rajendran & Samir Mardini Received: 5 September 2016 /Accepted: 6 November 2016 /Published online: 1 December 2016 Springer-Verlag Berlin Heidelberg 2016 Although randomized controlled trials (RCTs) are necessary non-compliance in study protocols—features that are relevant to rigorously test and compare therapeutics, the information to real-world clinical settings [3–5]. yielded by these trials can sometimes be limited. RCTs operate RCTs are necessary to test an intervention against a clearly under ideal conditions with a highly defined patient popula- defined control group. PCTs are particularly useful for head- to-head comparisons of therapies, including alternative treat- tion in a strictly controlled environment and may not always produce information that can be directly translated to improve ments and non-pharmacologic therapies. RCTs and PCTs also clinical decisions for a heterogeneous population. Often, the differ in outcome measurement. RCTs measure objective and effectiveness of interventions implemented from RCTs is quantifiable data to determine safety and efficacy. PCTs mea- diminished from those observed in clinical practice. The goal sure a broad, diverse set of outcomes, many of which may be of the pragmatic clinical trial (PCT) is to European Journal of Plastic Surgery Springer Journals

Pragmatic clinical trials: translating research into practice

Loading next page...
Springer Berlin Heidelberg
Copyright © 2016 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Plastic Surgery
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial