A simple, efficient and green method for the synthesis of 4,6-diaryl-2,3a,4,5-tetrahydro-3H-indazol-3-ones has been described using 3,5-diaryl-6-carbethoxy cyclohexenones in the presence of silica gel-supported polyphosphoric acid, an effective and reusable catalyst, under solvent-free conditions. The starting 3,5-diaryl-6-carbethoxy cyclohexenones have been synthesized by the Michael addition of chalcones and ethylacetoacetate followed by internal Claisen condensation using K2CO3 in solvent-free conditions. The present methodology offers several advantages, such as short reaction time, high yield, and the absence of volatile and hazardous organic solvents. Structural assignments are based on 1H, 13C NMR, FTIR, and C, H, N analysis.
Research on Chemical Intermediates – Springer Journals
Published: Oct 31, 2013
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