Potential Role of Allopurinol in Preventing Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Placebo-Controlled Trial

Potential Role of Allopurinol in Preventing Contrast-Induced Nephropathy in Patients Undergoing... Clin Drug Investig (2017) 37:853–860 DOI 10.1007/s40261-017-0542-z ORIGINAL RESEARCH ARTICLE Potential Role of Allopurinol in Preventing Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Placebo-Controlled Trial 1 2,3 3 • • • Zahra Ghelich Khan Azita Hajhossein Talasaz Hamidreza Pourhosseini 4 5 3 • • Kianoush Hosseini Mohammad Javad Alemzadeh Ansari Arash Jalali Published online: 12 June 2017 Springer International Publishing Switzerland 2017 Abstract C25% increase in serum cystatin-c relative to baseline, Background Contrast-induced nephropathy (CIN) is a failed to show a significant difference between the two major drawback in percutaneous coronary intervention groups. When adjusted on the baseline cystatin-c, SCr, sex, (PCI). Significant uricosuria has been reported following and positive family history, the difference in the overall contrast exposure. Allopurinol—a xanthine oxidase inhi- increase in serum cystatin-c was statistically significantly bitor—has been suggested to prevent the formation of lower in the allopurinol group. oxygen-free radicals, which may contribute to CIN. The Conclusions Allopurinol administration in patients under- aim of the present study was to evaluate the possible effi- going PCI failed to show efficacy in preventing CIN. cacy of allopurinol in preventing CIN. Nevertheless, this effect should be further evaluated in the Methods In this double-blind http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Drug Investigation Springer Journals

Potential Role of Allopurinol in Preventing Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Placebo-Controlled Trial

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing Switzerland
Subject
Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
ISSN
1173-2563
eISSN
1179-1918
D.O.I.
10.1007/s40261-017-0542-z
Publisher site
See Article on Publisher Site

Abstract

Clin Drug Investig (2017) 37:853–860 DOI 10.1007/s40261-017-0542-z ORIGINAL RESEARCH ARTICLE Potential Role of Allopurinol in Preventing Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Placebo-Controlled Trial 1 2,3 3 • • • Zahra Ghelich Khan Azita Hajhossein Talasaz Hamidreza Pourhosseini 4 5 3 • • Kianoush Hosseini Mohammad Javad Alemzadeh Ansari Arash Jalali Published online: 12 June 2017 Springer International Publishing Switzerland 2017 Abstract C25% increase in serum cystatin-c relative to baseline, Background Contrast-induced nephropathy (CIN) is a failed to show a significant difference between the two major drawback in percutaneous coronary intervention groups. When adjusted on the baseline cystatin-c, SCr, sex, (PCI). Significant uricosuria has been reported following and positive family history, the difference in the overall contrast exposure. Allopurinol—a xanthine oxidase inhi- increase in serum cystatin-c was statistically significantly bitor—has been suggested to prevent the formation of lower in the allopurinol group. oxygen-free radicals, which may contribute to CIN. The Conclusions Allopurinol administration in patients under- aim of the present study was to evaluate the possible effi- going PCI failed to show efficacy in preventing CIN. cacy of allopurinol in preventing CIN. Nevertheless, this effect should be further evaluated in the Methods In this double-blind

Journal

Clinical Drug InvestigationSpringer Journals

Published: Jun 12, 2017

References

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