Eur J Drug Metab Pharmacokinet https://doi.org/10.1007/s13318-018-0486-6 REVIEW AR TICLE Potential Inﬂuence of Centrally Acting Herbal Drugs on Transporters at the Blood–Cerebrospinal Fluid Barrier and Blood–Brain Barrier 1 2 3 1 • • • Lilian W. Kibathi SoHyun Bae Scott R. Penzak Parag Kumar Springer International Publishing AG, part of Springer Nature 2018 Abstract Complementary and alternative medications Key Points (CAM) with known or suspected pharmacologic activity in the central nervous system (CNS) are common. These A number of commonly used herbal preparations herbal preparations may cause clinically signiﬁcant drug– have the potential to modulate centrally located drug interactions (DDIs) when coadministered with medi- membrane transporters; this prompts concern for cations that act in the CNS. This can result in negative potential drug interactions between centrally acting outcomes such as toxicity or loss of efﬁcacy. Most drug conventional medications and herbal supplements. interaction reports with CAM focus on cytochrome P450 (CYP) modulation. However, drug interactions between The majority of drug interaction studies with herbal CAM and conventional medications may occur via mech- medications investigate their impact on CYP anisms other than CYP inhibition or induction; in partic- activity. The role and magnitude of CNS transporter- ular, modulation of drug transport
European Journal of of Drug Metabolism and Pharmacokinetics – Springer Journals
Published: Jun 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
Read and print from thousands of top scholarly journals.
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
ok to continue