Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Potential Influence of Centrally Acting Herbal Drugs on Transporters at the Blood–Cerebrospinal Fluid Barrier and Blood–Brain Barrier

Potential Influence of Centrally Acting Herbal Drugs on Transporters at the Blood–Cerebrospinal... Complementary and alternative medications (CAM) with known or suspected pharmacologic activity in the central nervous system (CNS) are common. These herbal preparations may cause clinically significant drug–drug interactions (DDIs) when coadministered with medications that act in the CNS. This can result in negative outcomes such as toxicity or loss of efficacy. Most drug interaction reports with CAM focus on cytochrome P450 (CYP) modulation. However, drug interactions between CAM and conventional medications may occur via mechanisms other than CYP inhibition or induction; in particular, modulation of drug transport proteins represents an important mechanism by which such interactions may occur. This article provides an updated review of transporter-mediated mechanisms by which herbal products may theoretically interact with centrally acting medications at the blood–brain barrier and blood–cerebrospinal fluid (CSF) barrier. Further research is required before the true clinical impact of interactions involving modulation of centrally located membrane transporters can be fully understood. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of of Drug Metabolism and Pharmacokinetics Springer Journals

Potential Influence of Centrally Acting Herbal Drugs on Transporters at the Blood–Cerebrospinal Fluid Barrier and Blood–Brain Barrier

Download PDF
17 pages

Loading next page...
 
/lp/springer_journal/potential-influence-of-centrally-acting-herbal-drugs-on-transporters-yiY0mPX1vY
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Human Physiology; Pharmaceutical Sciences/Technology; Medical Biochemistry
ISSN
0378-7966
eISSN
2107-0180
DOI
10.1007/s13318-018-0486-6
Publisher site
See Article on Publisher Site

Abstract

Complementary and alternative medications (CAM) with known or suspected pharmacologic activity in the central nervous system (CNS) are common. These herbal preparations may cause clinically significant drug–drug interactions (DDIs) when coadministered with medications that act in the CNS. This can result in negative outcomes such as toxicity or loss of efficacy. Most drug interaction reports with CAM focus on cytochrome P450 (CYP) modulation. However, drug interactions between CAM and conventional medications may occur via mechanisms other than CYP inhibition or induction; in particular, modulation of drug transport proteins represents an important mechanism by which such interactions may occur. This article provides an updated review of transporter-mediated mechanisms by which herbal products may theoretically interact with centrally acting medications at the blood–brain barrier and blood–cerebrospinal fluid (CSF) barrier. Further research is required before the true clinical impact of interactions involving modulation of centrally located membrane transporters can be fully understood.

Journal

European Journal of of Drug Metabolism and Pharmacokinetics – Springer Journals

Published: Jun 1, 2018

References

  • Traditional medicines: global situation, issues and challenges. The world medicines situation
    Robinson, MM; Zhang, X
  • Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national survey
    Eisenberg, DM; Davis, RB; Ettner, SL
  • Use of complementary and alternative medicine in patients with liver disease
    Strader, DB; Bacon, BR; Lindsay, KL
  • Use of alternative medicine by women with early-stage breast cancer
    Burstein, HJ; Gelber, S; Guadagnoli, E; Weeks, JC
  • The use of medicinal herbs by human immunodeficiency virus-infected patients
    Kassler, WJ; Blanc, P; Greenblatt, R
  • Alternative therapies among adults with a reported diagnosis of asthma or rhinosinusitis: data from a population-based survey
    Blanc, PD; Trupin, L; Earnest, G; Katz, PP; Yelin, EH; Eisner, MD
  • Use of herbal remedies by patients in a health maintenance organization
    Bennett, J; Brown, CM
  • Variability in commercial ginseng products: an analysis of 25 preparations
    Harkey, MR; Henderson, GL; Gershwin, ME; Stern, JS; Hackman, RM
  • Applied clinical pharmacokinetics and pharmacodynamics of psychopharmacological agents
    Jann, MW; Penzak, SR; Cohen, LJ
  • Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?
    Sanchez-Covarrubias, L; Slosky, LM; Thompson, BJ; Davis, TP; Ronaldson, PT
  • Human ABC transporters at blood–CNS interfaces as determinants of CNS drug penetration
    Chaves, C; Shawahna, R; Jacob, A; Scherrmann, J-M; Declèves, X
  • Establishment and dysfunction of the blood–brain barrier
    Zhao, Z; Nelson, AR; Betsholtz, C; Zlokovic, BV
  • Drug interactions with natural products at the blood brain barrier
    Fricker, G
  • Neuropharmacology of St. John’s Wort (Hypericum)
    Bennett, DA; Phun, L; Polk, JF; Voglino, SA; Zlotnik, V; Raffa, RB
  • Hypericum perforatum: a “modern” herbal antidepressant: pharmacokinetics of active ingredients
    Wurglics, M; Schubert-Zsilavecz, M
  • St. John’s wort induces hepatic drug metabolism through activation of the pregnane X receptor
    Moore, LB; Goodwin, B; Jones, SA
  • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    Geick, A; Eichelbaum, M; Burk, O
  • St Johns wort increases expression of P-glycoprotein: implications for drug interactions
    Hennessy, M; Kelleher, D; Spiers, JP
  • Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways
    Li, L; Stanton, JD; Tolson, AH; Luo, Y; Wang, H
  • Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway
    Awortwe, C; Manda, VK; Avonto, C
  • Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein
    Sugatani, J; Uchida, T; Kurosawa, M
  • Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor
    Rosenfeld, JM; Vargas, R; Xie, W; Evans, RM
  • Mania in a patient receiving testosterone replacement postorchidectomy taking St John’s wort and sertraline
    Barbenel, DM; Yusufi, B; O’Shea, D; Bench, CJ
  • Inhibition of P-glycoprotein by newer antidepressants
    Weiss, J; Dormann, S-MG; Martin-Facklam, M; Kerpen, CJ; Ketabi-Kiyanvash, N; Haefeli, WE
  • In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system
    Feng, B; Mills, JB; Davidson, RE
  • Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein
    Wang, J-S; Zhu, H-J; Gibson, BB; Markowitz, JS; Donovan, JL; DeVane, CL
  • Population pharmacokinetic analysis of drug–drug interactions among risperidone, bupropion, and sertraline in CF1 mice
    Wang, J-S; DeVane, CL; Gibson, BB; Donovan, JL; Markowitz, JS; Zhu, H-J
  • Possible serotonin syndrome after combination of buspirone and St John’s Wort
    Dannawi, M
  • Interaction of various Piper methysticum cultivars with CNS receptors in vitro
    Dinh, LD; Simmen, U; Bueter, KB; Bueter, B; Lundstrom, K; Schaffner, W
  • Online sources of herbal product information
    Owens, C; Baergen, R; Puckett, D
  • Proposal for a kava quality standardization code
    Teschke, R; Lebot, V
  • Role of ethanol in kava hepatotoxicity
    Li, XZ; Ramzan, I
  • Kava extracts: safety and risks including rare hepatotoxicity
    Teschke, R; Gaus, W; Loew, D
  • Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro
    Weiss, J; Sauer, A; Frank, A; Unger, M
  • Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans
    Gurley, BJ; Swain, A; Barone, GW
  • Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine [see comments]
    Fromm, MF; Kim, RB; Stein, CM; Wilkinson, GR; Roden, DM
  • In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates
    Rautio, J; Humphreys, JE; Webster, LO
  • Acute effects of kava, alone or in combination with alcohol, on subjective measures of impairment and intoxication and on cognitive performance
    Foo, H; Lemon, J
  • Coma from the health food store: interaction between kava and alprazolam
    Almeida, JC; Grimsley, EW
  • Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain
    Jussofie, A; Schmiz, A; Hiemke, C
  • Inhibition of human cytochrome P450 activities by kava extract and kavalactones
    Mathews, JM; Etheridge, AS; Black, SR
  • Anti-inflammatory effects of essential oil in Echinacea purpurea L
    Yu, D; Yuan, Y; Jiang, L
  • In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products
    Hellum, BH; Nilsen, OG
  • Gauging the clinical significance of P-glycoprotein-mediated herb–drug interactions: comparative effects of St. John’s wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics
    Gurley, BJ; Swain, A; Williams, DK; Barone, G; Battu, SK
  • Echinacea purpurea significantly induces cytochrome P450 3A activity but does not alter lopinavir-ritonavir exposure in healthy subjects
    Penzak, SR; Robertson, SM; Hunt, JD
  • Ginkgo biloba extract attenuates hippocampal neuronal loss and cognitive dysfunction resulting from trimethyltin in mice
    Kaur, S; Chhabra, R; Nehru, B
  • Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects
    Robertson, SM; Davey, RT; Voell, J; Formentini, E; Alfaro, RM; Penzak, SR
  • Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin
    Wang, Y; Cao, J; Zeng, S
  • Inhibition of hepatic uptake transporters by flavonoids
    Mandery, K; Balk, B; Bujok, K; Schmidt, I; Fromm, MF; Glaeser, H
  • Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans
    Hajda, J; Rentsch, KM; Gubler, C; Steinert, H; Stieger, B; Fattinger, K
  • HIV protease inhibitors: garlic supplements and first-pass intestinal metabolism impact on the therapeutic efficacy
    Berginc, K; Trdan, T; Trontelj, J; Kristl, A
  • The effect of garlic supplements on the pharmacokinetics of saquinavir
    Piscitelli, SC; Burstein, AH; Welden, N; Gallicano, KD; Falloon, J
  • An unusual case of HIV virologic failure during treatment with boosted atazanavir
    Duncan, A; Mills, J
  • The mechanisms responsible for garlic–drug interactions and their in vivo relevance
    Berginc, K; Kristl, A
  • Aged garlic extract stimulates p-glycoprotein and multidrug resistance associated protein 2 mediated effluxes
    Berginc, K; Zakelj, S; Ursic, D; Kristl, A
  • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    Kim, RB; Fromm, MF; Wandel, C
  • HIV-1-associated dementia during HAART therapy
    Aquaro, S; Svicher, V; Ronga, L; Perno, CF; Pollicita, M
  • Antiinflammatory principle of ephedra herbs
    Hikino, H; Konno, C; Takata, H; Tamada, M
  • Inhibitory effect of Ephedrae herba, an oriental traditional medicine, on the growth of influenza A/PR/8 virus in MDCK cells
    Mantani, N; Andoh, T; Kawamata, H; Terasawa, K; Ochiai, H
  • Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis
    Shekelle, PG; Hardy, ML; Morton, SC
  • Effects of herbal drugs in Mahuang decoction and their main components on intestinal transport characteristics of ephedra alkaloids evaluated by a Caco-2 cell monolayer model
    Zheng, M; Zhou, H; Wan, H; Chen, Y-L; He, Y
  • Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea
    Diepvens, K; Westerterp, KR; Westerterp-Plantenga, MS
  • Inhibitory effects of furanocoumarin derivatives in Kampo extract medicines on P-glycoprotein at the blood–brain barrier
    Iwanaga, K; Yoneda, S; Hamahata, Y
  • Importance of drug pharmacokinetics at the site of action
    Rizk, ML; Zou, L; Savic, RM; Dooley, KE
  • Evaluation of transporters in drug development: current status and contemporary issues
    Lee, S-C; Arya, V; Yang, X; Volpe, DA; Zhang, L
  • Kava: a comprehensive review of efficacy, safety, and psychopharmacology
    Sarris, J; LaPorte, E; Schweitzer, I
  • The antinociceptive actions of kava components in mice
    Jamieson, DD; Duffield, PH
  • Hypericum perforatum (St John’s wort) beyond depression: a therapeutic perspective for pain conditions
    Galeotti, N
  • Hypericum perforatum—a review of clinical studies
    Kasper, S
  • St John’s wort: a potential therapy for elderly depressed patients?
    Vorbach, EU; Arnoldt, KH; Wolpert, E
  • Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John’s Wort
    Röder, C; Schaefer, M; Leucht, S
  • Ginkgo biloba attenuates oxidative DNA damage of human umbilical vein endothelial cells induced by intermittent high glucose
    He, Y-T; Xing, S-S; Gao, L; Wang, J; Xing, Q-C; Zhang, W
  • The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux
    An, G; Gallegos, J; Morris, ME
  • Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B
    Fuchikami, H; Satoh, H; Tsujimoto, M; Ohdo, S; Ohtani, H; Sawada, Y
  • Effects of Ginkgo biloba extract ingestion on the pharmacokinetics of talinolol in healthy Chinese volunteers
    Fan, L; Tao, G-Y; Wang, G
  • Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers
    Fan, L; Mao, X-Q; Tao, G-Y
  • Interactions between herbal medicines and prescribed drugs: an updated systematic review
    Izzo, AA; Ernst, E
  • Panax ginseng and Panax quinquefolius: from pharmacology to toxicology
    Mancuso, C; Santangelo, R
  • Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation
    Endale, M; Lee, WM; Kamruzzaman, SM
  • Treating pregnancy-related nausea and vomiting with ginger
    Boone, SA; Shields, KM
  • A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP)
    Sharifzadeh, F; Kashanian, M; Koohpayehzadeh, J; Rezaian, F; Sheikhansari, N; Eshraghi, N
  • A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting
    Viljoen, E; Visser, J; Koen, N; Musekiwa, A
  • Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism
    Srivastava, KC
  • A review of the antiviral role of green tea catechins
    Xu, J; Xu, Z; Zheng, W
  • Colorectal cancer and inflammatory bowel diseases: effects of diet and antioxidants
    Carini, F; Tomasello, G; Jurjus, A
  • The influence of dietary factors in central nervous system plasticity and injury recovery
    Gomez-Pinilla, F; Gomez, AG
  • Biological properties of garlic and garlic-derived organosulfur compounds
    Iciek, M; Kwiecień, I; Włodek, L
  • Neuroprotective effects of aged garlic extract on cognitive dysfunction and neuroinflammation induced by β-amyloid in rats
    Nillert, N; Pannangrong, W; Welbat, JU; Chaijaroonkhanarak, W; Sripanidkulchai, K; Sripanidkulchai, B
  • Garlic: a review of potential therapeutic effects
    Bayan, L; Koulivand, PH; Gorji, A
  • Garlic (Allium sativum)—a potent medicinal plant
    Resch, KL; Ernst, E
  • Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions
    Steiner, M; Li, W
  • Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies
    Yeh, YY; Liu, L
  • The pharmacology of psychoactive alkaloids from ephedra and catha
    Kalix, P
  • Plants and the central nervous system
    Carlini, EA
  • The non-estrogenic alternative for the treatment of climacteric complaints: black cohosh (Cimicifuga or Actaea racemosa)
    Wuttke, W; Jarry, H; Haunschild, J; Stecher, G; Schuh, M; Seidlova-Wuttke, D
  • Pharmacological effects of Cimicifuga racemosa
    Borrelli, F; Izzo, AA; Ernst, E
  • Black cohosh: efficacy, safety, and use in clinical and preclinical applications
    McKenna, DJ; Jones, K; Humphrey, S; Hughes, K
  • A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause
    Lieberman, S
  • P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood–brain barrier in vivo
    Bundgaard, C; Eneberg, E; Sánchez, C
  • Sertraline alters multidrug resistance phosphoglycoprotein activity in the mouse placenta and fetal blood–brain barrier
    Bhuiyan, M; Petropoulos, S; Gibb, W; Matthews, SG
  • Effect of venlafaxine and desvenlafaxine on drug efflux protein expression and biodistribution in vivo
    Bachmeier, C; Levin, GM; Beaulieu-Abdelahad, D; Reed, J; Mullan, M
  • Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood–brain barrier permeability
    O’Brien, FE; Clarke, G; Dinan, TG; Cryan, JF; Griffin, BT
  • Impact of genetic deficiencies of P-glycoprotein and breast cancer resistance protein on pharmacokinetics of aripiprazole and dehydroaripiprazole
    Nagasaka, Y; Sano, T; Oda, K; Kawamura, A; Usui, T
  • Pharmacodynamic effects of aripiprazole and ziprasidone with respect to p-glycoprotein substrate properties
    Holthoewer, D; Kirschbaum, KM; Frisch, J; Hiemke, C; Schmitt, U
  • Antipsychotic drugs inhibit the function of breast cancer resistance protein
    Wang, J-S; Zhu, H-J; Markowitz, JS; Donovan, JL; Yuan, H-J; Devane, CL
  • P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists
    Chen, C; Hanson, E; Watson, JW; Lee, JS
  • P-glycoprotein in the blood–brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    Schinkel, AH; Wagenaar, E; Mol, CA; Deemter, L
  • Mice with neuropathic pain exhibit morphine tolerance due to a decrease in the morphine concentration in the brain
    Ochiai, W; Kaneta, M; Nagae, M
  • The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2)
    Römermann, K; Helmer, R; Löscher, W
  • P-glycoprotein alters blood–brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy
    Ma, A; Wang, C; Chen, Y; Yuan, W
  • Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models
    Nakanishi, H; Yonezawa, A; Matsubara, K; Yano, I
  • Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood–brain barrier in a rat brain endothelial cell model
    Vautier, S; Milane, A; Fernandez, C; Buyse, M; Chacun, H; Farinotti, R
  • Local drug–drug interaction of donepezil with cilostazol at breast cancer resistance protein (ABCG2) increases drug accumulation in heart
    Takeuchi, R; Shinozaki, K; Nakanishi, T; Tamai, I
  • Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals
    Nabekura, T; Yamaki, T; Ueno, K; Kitagawa, S
  • Effect of garlic, gingko, and St. John’s Wort extracts on the pharmacokinetics of fexofenadine: a mechanistic study
    Turkanovic, J; Ward, MB; Gerber, JP; Milne, RW
  • Single pre-treatment with hypericin, a St. John’s wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells
    Jendželovská, Z; Jendželovský, R; Hiľovská, L; Kovaľ, J; Mikeš, J; Fedoročko, P
  • Comparison of the synaptosomal uptake inhibition of serotonin by St John’s wort products
    Schulte-Löbbert, S; Holoubek, G; Müller, WE; Schubert-Zsilavecz, M; Wurglics, M
  • Common herbal dietary supplement-drug interactions
    Asher, GN; Corbett, AH; Hawke, RL
  • Echinacea purpurea and P-glycoprotein drug transport in Caco-2 cells
    Hansen, TS; Nilsen, OG
  • Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng
    Choi, C-H; Kang, G; Min, Y-D
  • Metabolites of ginsenosides as novel BCRP inhibitors
    Jin, J; Shahi, S; Kang, HK; Veen, HW; Fan, T-P
  • Effects of dietary chemopreventive phytochemicals on P-glycoprotein function
    Nabekura, T; Kamiyama, S; Kitagawa, S
  • Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols
    Jodoin, J; Demeule, M; Beliveau, R
  • Inhibitory effects of green tea and (-)-epigallocatechin gallate on transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein
    Knop, J; Misaka, S; Singer, K
  • Ingredients in fruit juices interact with dasatinib through inhibition of BCRP: a new mechanism of beverage–drug interaction
    Fleisher, B; Unum, J; Shao, J; An, G
  • Inhibitory activity of a green tea extract and some of its constituents on multidrug resistance-associated protein 2 functionality
    Netsch, MI; Gutmann, H; Luescher, S
  • Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
    Zhang, S; Morris, ME
  • Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids
    Tamaki, H; Satoh, H; Hori, S; Ohtani, H; Sawada, Y
  • Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-κB activation and HSP70 up-regulation
    Xin, Y; Yin, F; Qi, S
  • Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans
    Gurley, BJ; Barone, GW; Williams, DK
  • Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
    Lown, KS; Mayo, RR; Leichtman, AB
  • 6′,7′-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein
    Edwards, DJ; Fitzsimmons, ME; Schuetz, EG
  • Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4
    Ohnishi, A; Matsuo, H; Yamada, S
  • Grapefruit juice–drug interactions: grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells
    Castro, WV; Mertens-Talcott, S; Derendorf, H; Butterweck, V
  • Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine
    Paine, MF; Widmer, WW; Pusek, SN
  • Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein
    Dahan, A; Amidon, GL
  • St John’s wort greatly decreases the plasma concentrations of oral S-ketamine
    Peltoniemi, MA; Saari, TI; Hagelberg, NM; Laine, K; Neuvonen, PJ; Olkkola, KT
  • Drug interaction between St John’s wort and zolpidem in healthy subjects
    Hojo, Y; Echizenya, M; Ohkubo, T; Shimizu, T
  • Effect of St. John’s wort supplementation on the pharmacokinetics of bupropion in healthy male Chinese volunteers
    Lei, H-P; Yu, X-Y; Xie, H-T
  • St John’s wort greatly reduces the concentrations of oral oxycodone
    Nieminen, TH; Hagelberg, NM; Saari, TI
  • Effect of St John’s wort on the pharmacokinetics of fexofenadine
    Wang, Z; Hamman, MA; Huang, S-M; Lesko, LJ; Hall, SD
  • Coordinate induction of both cytochrome P4503A and MDR1 by St John’s wort in healthy subjects
    Dresser, GK; Schwarz, UI; Wilkinson, GR; Kim, RB
  • Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John’s wort (Hypericum perforatum)
    Johne, A; Schmider, J; Brockmöller, J
  • Pharmacodynamic and pharmacokinetic interactions of propranolol with garlic (Allium sativum) in rats
    Asdaq, SMB; Inamdar, MN
  • Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers
    Markowitz, JS; Devane, CL; Chavin, KD; Taylor, RM; Ruan, Y; Donovan, JL
  • Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John’s wort, garlic oil, Panax ginseng and Ginkgo biloba
    Gurley, BJ; Gardner, SF; Hubbard, MA