Postsynaptic cutaneous vasodilation and sweating: influence of adiposity and hydration status

Postsynaptic cutaneous vasodilation and sweating: influence of adiposity and hydration status Introduction Obesity and hypohydration independently affect postsynaptic endothelial function, but it is unknown if hypo- hydration affects lean and obese individuals differently. Purpose To examine the effect of hypohydration on postsynaptic cutaneous vasodilation and sweating in men with high and low adiposity (HI- and LO-BF, respectively). Methods Ten males with LO-BF and ten with HI-BF were instrumented for forearm microdialysis when euhydrated and hypohydrated. Changes in cutaneous vascular conductance (CVC) with intradermal infusion of sodium nitroprusside (SNP) and methacholine chloride (MCh) were assessed. Local sweat rate (LSR) was simultaneously assessed at the MCh site. At the end of the last dose, maximal CVC was elicited by delivering a maximal dose of SNP for 30 min to both sites with simultaneous local heating at the SNP site. The concentration of drug needed to elicit 50% of the maximal response (EC ) was compared between groups and hydration conditions. Results When euhydrated, EC of MCh-induced CVC was not different between LO- vs. HI-BF [− 3.04 ± 0.12 vs. − 2.98 ± 0.19 log (MCh) M, P = 0.841]. EC of SNP-induced CVC was higher in euhydrated HI- vs. LO-BF (− 1.74 ± 0.17 vs. − 2.13 ± 0.06 log (SNP) M, P http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Applied Physiology Springer Journals

Postsynaptic cutaneous vasodilation and sweating: influence of adiposity and hydration status

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Biomedicine; Human Physiology; Occupational Medicine/Industrial Medicine; Sports Medicine
ISSN
1439-6319
eISSN
1439-6327
D.O.I.
10.1007/s00421-018-3902-3
Publisher site
See Article on Publisher Site

Abstract

Introduction Obesity and hypohydration independently affect postsynaptic endothelial function, but it is unknown if hypo- hydration affects lean and obese individuals differently. Purpose To examine the effect of hypohydration on postsynaptic cutaneous vasodilation and sweating in men with high and low adiposity (HI- and LO-BF, respectively). Methods Ten males with LO-BF and ten with HI-BF were instrumented for forearm microdialysis when euhydrated and hypohydrated. Changes in cutaneous vascular conductance (CVC) with intradermal infusion of sodium nitroprusside (SNP) and methacholine chloride (MCh) were assessed. Local sweat rate (LSR) was simultaneously assessed at the MCh site. At the end of the last dose, maximal CVC was elicited by delivering a maximal dose of SNP for 30 min to both sites with simultaneous local heating at the SNP site. The concentration of drug needed to elicit 50% of the maximal response (EC ) was compared between groups and hydration conditions. Results When euhydrated, EC of MCh-induced CVC was not different between LO- vs. HI-BF [− 3.04 ± 0.12 vs. − 2.98 ± 0.19 log (MCh) M, P = 0.841]. EC of SNP-induced CVC was higher in euhydrated HI- vs. LO-BF (− 1.74 ± 0.17 vs. − 2.13 ± 0.06 log (SNP) M, P

Journal

European Journal of Applied PhysiologySpringer Journals

Published: May 31, 2018

References

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