Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. John, D. Cesario, J. Weiss (2003)
Gap junctional hemichannels in the heart.Acta physiologica Scandinavica, 179 1
V. Valiunas (2002)
Biophysical Properties of Connexin-45 Gap Junction Hemichannels Studied in Vertebrate CellsThe Journal of General Physiology, 119
E. Trexler, M. Bennett, T. Bargiello, V. Verselis (1996)
Voltage gating and permeation in a gap junction hemichannel.Proceedings of the National Academy of Sciences of the United States of America, 93 12
P. Brookes, Y. Yoon, J. Robotham, M. Anders, S. Sheu (2004)
Calcium, ATP, and ROS: a mitochondrial love-hate triangle.American journal of physiology. Cell physiology, 287 4
W. Evans, E. Vuyst, Luc Leybaert (2006)
The gap junction cellular internet: connexin hemichannels enter the signalling limelight.The Biochemical journal, 397 1
R. Adibhatla, James Hatcher, R. Dempsey (2006)
Lipids and lipidomics in brain injury and diseasesThe AAPS Journal, 8
C. Borges, T. Geddes, J. Watson, D. Kuhn (2002)
Dopamine biosynthesis is regulated by S-glutathionylation. Potential mechanism of tyrosine hydroxylast inhibition during oxidative stress.The Journal of biological chemistry, 277 50
A. Ngezahayo, C. Zeilinger, I. Todt, I. Marten, H. Kolb (1998)
Inactivation of expressed and conducting rCx46 hemichannels by phosphorylationPflügers Archiv, 436
F. Bukauskas, M. Kreuzberg, M. Rackauskas, Angele Bukauskiene, M. Bennett, V. Verselis, K. Willecke (2006)
Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart.Proceedings of the National Academy of Sciences of the United States of America, 103 25
A. Nieminen (2003)
Apoptosis and necrosis in health and disease: role of mitochondria.International review of cytology, 224
L. Musil, D. Goodenough (1993)
Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ERCell, 74
JE Contreras, HA Sánchez, LP Véliz, FF Bukauskas, MV Bennett, JC Sáez (2004)
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissueBrain Res Brain Res Rev, 47
C. Borges, T. Geddes, J. Watson, D. Kuhn (2002)
Dopamine Biosynthesis Is Regulated byS-GlutathionylationThe Journal of Biological Chemistry, 277
Jean Jiang, S. Gu (2005)
Gap junction- and hemichannel-independent actions of connexins.Biochimica et biophysica acta, 1711 2
M. Barbe, H. Monyer, R. Bruzzone (2006)
Cell-cell communication beyond connexins: the pannexin channels.Physiology, 21
L. Ebihara, Xiaoqin Liu, J. Pal (2003)
Effect of external magnesium and calcium on human connexin46 hemichannels.Biophysical journal, 84 1
S. Capes, D. Hunt, K. Malmberg, Parbeen Pathak, H. Gerstein (2001)
Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic OverviewStroke: Journal of the American Heart Association, 32
J. Contreras, Helmuth Sánchez, Loreto Véliz, F. Bukauskas, M. Bennett, J. Sáez (2004)
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissueBrain Research Reviews, 47
AD Martínez, JC Sáez (2000)
Regulation of astrocyte gap junctions by hypoxia-reoxygenationBrain Res Brain Res Rev, 32
P. Pelegrín, A. Surprenant (2006)
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptorThe EMBO Journal, 25
Jun-Jie Tong, L. Ebihara (2006)
Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels.Biophysical journal, 91 6
P. Mergenthaler, U. Dirnagl, A. Meisel (2004)
Pathophysiology of Stroke: Lessons from Animal ModelsMetabolic Brain Disease, 19
S. John, R. Kondo, Sheng-Yong Wang, J. Goldhaber, J. Weiss (1999)
Connexin-43 Hemichannels Opened by Metabolic Inhibition*The Journal of Biological Chemistry, 274
M. Cotrina, Jian Kang, J. Lin, E. Bueno, T. Hansen, L. He, Yulin Liu, M. Nedergaard (1998)
Astrocytic Gap Junctions Remain Open during Ischemic ConditionsThe Journal of Neuroscience, 18
Cindy Wong, T. Christen, I. Roth, C. Chadjichristos, Jean-Paul Derouette, B. Foglia, M. Chanson, D. Goodenough, B. Kwak (2006)
Connexin37 protects against atherosclerosis by regulating monocyte adhesionNature Medicine, 12
X. Bao, Yongyue Chen, L. Reuss, G. Altenberg (2004)
Functional Expression in Xenopus Oocytes of Gap-junctional Hemichannels Formed by a Cysteine-less Connexin 43*Journal of Biological Chemistry, 279
B. Siesjö, Ken-ichiro Katsura, Qi Zhao, J. Folbergrová, Kerstin Pahlmark, Peter Siesjö, Maj-lis Smith (1995)
Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis.Journal of neurotrauma, 12 5
B. Warn-Cramer, G. Cottrell, J. Burt, A. Lau (1998)
Regulation of Connexin-43 Gap Junctional Intercellular Communication by Mitogen-activated Protein Kinase*The Journal of Biological Chemistry, 273
J. Stamler (1994)
Redox signaling: Nitrosylation and related target interactions of nitric oxideCell, 78
X. Bao, L. Reuss, G. Altenberg (2004)
Regulation of Purified and Reconstituted Connexin 43 Hemichannels by Protein Kinase C-mediated Phosphorylation of Serine 368*Journal of Biological Chemistry, 279
Tai-feng Liu, R. Johnson (1999)
Effects of TPA on dye transfer and dye leakage in fibroblasts transfected with a connexin 43 mutation at ser368.Methods and findings in experimental and clinical pharmacology, 21 6
M. Romanello, V. Veronesi, P. D'andrea (2003)
Mechanosensitivity and intercellular communication in HOBIT osteoblastic cells: a possible role for gap junction hemichannels.Biorheology, 40 1-3
M. Retamal, Constanza Cortes, L. Reuss, M. Bennett, J. Sáez (2006)
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents.Proceedings of the National Academy of Sciences of the United States of America, 103 12
Priscilla Cherian, Arlene Siller-Jackson, S. Gu, Xin Wang, L. Bonewald, E. Sprague, Jean Jiang (2005)
Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin.Molecular biology of the cell, 16 7
R. Bruzzone, S. Hormuzdi, M. Barbe, A. Herb, H. Monyer (2003)
Pannexins, a family of gap junction proteins expressed in brainProceedings of the National Academy of Sciences of the United States of America, 100
C. Abrams, M. Bennett, V. Verselis, T. Bargiello (2002)
Voltage opens unopposed gap junction hemichannels formed by a connexin 32 mutant associated with X-linked Charcot-Marie-Tooth diseaseProceedings of the National Academy of Sciences of the United States of America, 99
Charles Stout, A. Charles (2003)
Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesiumGlia, 43
A. Katz, F. Messineo (1981)
Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium.Circulation research, 48 1
S. Bruzzone, L. Guida, E. Zocchi, L. Franco, A. Flora (2001)
Connexin 43 hemichannels mediate Ca2+‐regulated transmembrane NAD+ fluxes in intact cellsThe FASEB Journal, 15
Mark Turner, Mark Turner, G. Haywood, P. Andréka, Lijing You, Patricia Martin, W. Evans, K. Webster, N. Bishopric (2004)
Reversible Connexin 43 Dephosphorylation During Hypoxia and Reoxygenation Is Linked to Cellular ATP LevelsCirculation Research, 95
Dwan Gerido, Adam Derosa, G. Richard, T. White (2007)
Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness.American journal of physiology. Cell physiology, 293 1
G. Zampighi, D. Loo, M. Kreman, S. Eskandari, E. Wright (1999)
Functional and Morphological Correlates of Connexin50 Expressed in Xenopus laevis OocytesThe Journal of General Physiology, 113
M. Bennett, J. Contreras, F. Bukauskas, J. Sáez (2003)
New roles for astrocytes: Gap junction hemichannels have something to communicateTrends in Neurosciences, 26
D. Zhang, D. Mcmahon (2001)
Gating of retinal horizontal cell hemi gap junction channels by voltage, Ca2+, and retinoic acid.Molecular vision, 7
M. Beardslee, D. Lerner, P. Tadros, J. Laing, E. Beyer, Kathryn Yamada, A. Kleber, R. Schuessler, J. Saffitz (2000)
Dephosphorylation and Intracellular Redistribution of Ventricular Connexin43 During Electrical Uncoupling Induced by IschemiaCirculation Research: Journal of the American Heart Association, 87
M. Elahi, B. Matata (2006)
Free radicals in blood: evolving concepts in the mechanism of ischemic heart disease.Archives of biochemistry and biophysics, 450 1
F. Giordano (2005)
Oxygen, oxidative stress, hypoxia, and heart failure.The Journal of clinical investigation, 115 3
K. Boengler, G. Dodoni, A. Rodríguez-Sinovas, A. Cabestrero, M. Ruiz-Meana, P. Gres, I. Konietzka, C. López-Iglesias, D. Garcia-Dorado, F. Lisa, G. Heusch, R. Schulz (2005)
Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning.Cardiovascular research, 67 2
Lisa Ebihara, V. Berthoud, Eric Beyer (1995)
Distinct behavior of connexin56 and connexin46 gap junctional channels can be predicted from the behavior of their hemi-gap-junctional channels.Biophysical journal, 68 5
(2004)
Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina
D. Bano, P. Nicotera (2007)
Ca2+ Signals and Neuronal Death in Brain IschemiaStroke, 38
B. Stong, Q. Chang, Shoeb Ahmad, Xi Lin (2006)
A Novel Mechanism for Connexin 26 Mutation Linked Deafness: Cell Death Caused by Leaky Gap Junction HemichannelsThe Laryngoscope, 116
Z. Xiong, Xiao-man Zhu, X. Chu, M. Minami, Jessica Hey, Wenlin Wei, J. Macdonald, J. Wemmie, M. Price, M. Welsh, R. Simon (2004)
Neuroprotection in Ischemia Blocking Calcium-Permeable Acid-Sensing Ion ChannelsCell, 118
H. Takeuchi, Shijie Jin, Jinyan Wang, Guiqin Zhang, J. Kawanokuchi, R. Kuno, Yoshifumi Sonobe, T. Mizuno, A. Suzumura (2006)
Tumor Necrosis Factor-α Induces Neurotoxicity via Glutamate Release from Hemichannels of Activated Microglia in an Autocrine Manner*Journal of Biological Chemistry, 281
L. Ebihara (1996)
Xenopus connexin38 forms hemi-gap-junctional channels in the nonjunctional plasma membrane of Xenopus oocytes.Biophysical journal, 71 2
G. Richard (2003)
Connexin gene pathologyClinical and Experimental Dermatology, 28
F. Li, K. Sugishita, Z. Su, I. Ueda, W. Barry (2001)
Activation of connexin-43 hemichannels can elevate [Ca(2+)]i and [Na(+)]i in rabbit ventricular myocytes during metabolic inhibition.Journal of molecular and cellular cardiology, 33 12
Michael Puljung, V. Berthoud, E. Beyer, D. Hanck (2004)
Polyvalent Cations Constitute the Voltage Gating Particle in Human Connexin37 HemichannelsThe Journal of General Physiology, 124
Richard Kondo, Sheng-Yong Wang, S. John, James Weiss, J. Goldhaber (2000)
Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes.Journal of molecular and cellular cardiology, 32 10
Jinshu Yu, Christian Bippes, G. Hand, Daniel Muller, G. Sosinsky (2007)
Aminosulfonate Modulated pH-induced Conformational Changes in Connexin26 Hemichannels*Journal of Biological Chemistry, 282
R. Sacco, J. Chong, S. Prabhakaran, M. Elkind (2007)
Experimental treatments for acute ischaemic strokeThe Lancet, 369
Li Bao, S. Locovei, G. Dahl (2004)
Pannexin membrane channels are mechanosensitive conduits for ATPFEBS Letters, 572
K. Muir (2002)
Magnesium in stroke treatmentPostgraduate Medical Journal, 78
A. Quist, S. Rhee, Hai Lin, R. Lal (2000)
Physiological Role of Gap-Junctional Hemichannels: Extracellular Calcium-Dependent Isosmotic Volume RegulationJournal of Cell Biology, 148
T. Yamamoto, A. Ochalski, Elliot Hertzberg, James Nagy (1990)
LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brainBrain Research, 508
Hong-Bo Zhao (2005)
Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communicationsEuropean Journal of Neuroscience, 21
P. Mancuso, C. Canetti, Andrew Gottschalk, P. Tithof, M. Peters-Golden (2004)
Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression.American journal of physiology. Lung cellular and molecular physiology, 287 3
M. Broillet (1999)
S-Nitrosylation of proteinsCellular and Molecular Life Sciences CMLS, 55
G. Gaietta, T. Deerinck, S. Adams, J. Bouwer, Oded Tour, D. Laird, G. Sosinsky, R. Tsien, Mark Ellisman (2002)
Multicolor and Electron Microscopic Imaging of Connexin TraffickingScience, 296
Zhenggang Zhang, M. Chopp, F. Bailey, T. Malinski (1995)
Nitric oxide changes in the rat brain after transient middle cerebral artery occlusionJournal of the Neurological Sciences, 128
©2005 FASEB The FASEB Journal express article 10.1096/fj.05-4110fje. Published online October 4, 2005. Regulation of noncapacitative calcium entry by arachidonic acid and nitric oxide in endothelial cells
Matthias Falk, N. Kumar, N. Gilula (1994)
Membrane insertion of gap junction connexins: polytopic channel forming membrane proteinsThe Journal of Cell Biology, 127
Roger Thompson, N. Zhou, B. MacVicar (2006)
Ischemia Opens Neuronal Gap Junction HemichannelsScience, 312
W. Li, J. Nagy (2000)
Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibitionEuropean Journal of Neuroscience, 12
Sanyukta Rana, R. Dringen (2007)
Gap junction hemichannel-mediated release of glutathione from cultured rat astrocytesNeuroscience Letters, 415
C. Cooper, P. Lampe (2002)
Casein Kinase 1 Regulates Connexin-43 Gap Junction Assembly*The Journal of Biological Chemistry, 277
R. Bruzzone, M. Barbe, N. Jakob, H. Monyer (2005)
Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytesJournal of Neurochemistry, 92
J. Contreras, J. Sáez, F. Bukauskas, M. Bennett (2003)
Gating and regulation of connexin 43 (Cx43) hemichannelsProceedings of the National Academy of Sciences of the United States of America, 100
R. Malchow, R. Malchow, H. Qian, H. Ripps, H. Ripps (1993)
Evidence for hemi‐gap junctional channels in isolated horizontal cells of the skate retinaJournal of Neuroscience Research, 35
Laia Bahima, J. Aleu, M. Elias, M. Martín-Satué, Ashraf Muhaisen, J. Blasi, J. Marsal, C. Solsona (2006)
Endogenous hemichannels play a role in the release of ATP from Xenopus oocytesJournal of Cellular Physiology, 206
Shaohong Cheng, Teresa Shakespeare, R. Mui, T. White, G. Valdimarsson (2004)
Connexin 48.5 Is Required for Normal Cardiovascular Function and Lens Development in Zebrafish Embryos*[boxs]Journal of Biological Chemistry, 279
J. Contreras, Helmuth Sánchez, E. Eugenin, Dina Speidel, M. Theis, K. Willecke, F. Bukauskas, M. Bennett, J. Sáez (2001)
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in cultureProceedings of the National Academy of Sciences of the United States of America, 99
M. Pottek, W. Hoppenstedt, U. Janssen-Bienhold, K. Schultz, I. Perlman, R. Weiler (2003)
Contribution of connexin26 to electrical feedback inhibition in the turtle retinaJournal of Comparative Neurology, 466
I. Fahrenfort, T. Sjoerdsma, Harris Ripps, M. Kamermans (2004)
Cobalt ions inhibit negative feedback in the outer retina by blocking hemichannels on horizontal cellsVisual Neuroscience, 21
D. Goodenough, D. Paul (2003)
Beyond the gap: functions of unpaired connexon channelsNature Reviews Molecular Cell Biology, 4
Li Bao, F. Sachs, G. Dahl (2004)
Connexins are mechanosensitive.American journal of physiology. Cell physiology, 287 5
Askiel Bruno, J. Biller, H. Adams, W. Clarke, R. Woolson, L. Williams, M. Hansen (1999)
Acute blood glucose level and outcome from ischemic strokeNeurology, 52
Yan Huang, J. Grinspan, C. Abrams, S. Scherer (2007)
Pannexin1 is expressed by neurons and glia but does not form functional gap junctionsGlia, 55
D. Ford, S. Hazen, J. Saffitz, Richard Gross (1991)
The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia.The Journal of clinical investigation, 88 1
D. Hess, Akio Matsumoto, Sung-Oog Kim, H. Marshall, J. Stamler (2005)
Protein S-nitrosylation: purview and parametersNature Reviews Molecular Cell Biology, 6
H. Ripps, H. Qian, J. Zakevicius (2002)
Pharmacological enhancement of hemi-gap-junctional currents in Xenopus oocytesJournal of Neuroscience Methods, 121
A. Pfahnl, G. Dahl (1999)
Gating of cx46 gap junction hemichannels by calcium and voltagePflügers Archiv, 437
M. Retamal, K. Schalper, K. Shoji, M. Bennett, J. Sáez (2007)
Opening of connexin 43 hemichannels is increased by lowering intracellular redox potentialProceedings of the National Academy of Sciences, 104
P. Lampe, A. Lau (2004)
The effects of connexin phosphorylation on gap junctional communication.The international journal of biochemistry & cell biology, 36 7
P. Bader, R. Weingart (2004)
Conductive and Kinetic Properties of Connexin45 Hemichannels Expressed in Transfected HeLa CellsThe Journal of Membrane Biology, 199
T. White, Michael Deans, J. O'Brien, M. Al-Ubaidi, D. Goodenough, H. Ripps, R. Bruzzone (1999)
Functional characteristics of skate connexin35, a member of the γ subfamily of connexins expressed in the vertebrate retinaEuropean Journal of Neuroscience, 11
V. Valiunas, R. Mui, E. McLachlan, G. Valdimarsson, P. Brink, T. White (2004)
Biophysical characterization of zebrafish connexin35 hemichannels.American journal of physiology. Cell physiology, 287 6
H. Ripps, H. Qian, J. Zakevicius (2004)
Properties of Connexin26 Hemichannels Expressed in Xenopus OocytesCellular and Molecular Neurobiology, 24
J. Sáez, M. Retamal, D. Basílio, F. Bukauskas, M. Bennett (2005)
Connexin-based gap junction hemichannels: gating mechanisms.Biochimica et biophysica acta, 1711 2
V. Gupta, V. Berthoud, N. Atal, J. Jarillo, L. Barrio, E. Beyer (1994)
Bovine connexin44, a lens gap junction protein: molecular cloning, immunologic characterization, and functional expression.Investigative ophthalmology & visual science, 35 10
R. Pearson, N. Dale, E. Llaudet, P. Mobbs (2005)
ATP Released via Gap Junction Hemichannels from the Pigment Epithelium Regulates Neural Retinal Progenitor ProliferationNeuron, 46
A. Kader, V. Frazzini, R. Solomon, R. Trifiletti (1993)
Nitric Oxide Production During Focal Cerebral Ischemia in RatsStroke, 24
J. Gómez-Hernandez, M. Miguel, B. Larrosa, Daniel González, L. Barrio (2003)
Molecular basis of calcium regulation in connexin-32 hemichannelsProceedings of the National Academy of Sciences of the United States of America, 100
A. Ahmad, Sofiyan Saleem, Muzamil Ahmad, S. Doré (2006)
Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage.Toxicological sciences : an official journal of the Society of Toxicology, 89 1
Charles Stout, J. Costantin, C. Naus, A. Charles (2002)
Intercellular Calcium Signaling in Astrocytes via ATP Release through Connexin Hemichannels*The Journal of Biological Chemistry, 277
Daniel González, J. Gómez-Hernandez, Luis Barrio1 (2006)
Species specificity of mammalian connexin‐26 to form open voltage‐gated hemichannelsThe FASEB Journal, 20
D. Francis, K. Stergiopoulos, J. Ek-Vitorin, F. Cao, S. Taffet, M. Delmar (1999)
Connexin diversity and gap junction regulation by pHi.Developmental genetics, 24 1-2
Charles Stout, D. Goodenough, D. Paul (2004)
Connexins: functions without junctions.Current opinion in cell biology, 16 5
P. Gomes, S. Srinivas, W. Driessche, J. Vereecke, B. Himpens (2005)
ATP release through connexin hemichannels in corneal endothelial cells.Investigative ophthalmology & visual science, 46 4
Gregory Arcuino, J. Lin, T. Takano, Collins Liu, Li Jiang, Qun Gao, Jian Kang, M. Nedergaard (2002)
Intercellular calcium signaling mediated by point-source burst release of ATPProceedings of the National Academy of Sciences of the United States of America, 99
S. Eskandari, G. Zampighi, D. Leung, E. Wright, D. Loo (2002)
Inhibition of Gap Junction Hemichannels by Chloride Channel BlockersThe Journal of Membrane Biology, 185
E. Vuyst, E. Decrock, L. Cabooter, G. Dubyak, C. Naus, W. Evans, L. Leybaert (2006)
Intracellular calcium changes trigger connexin 32 hemichannel openingThe EMBO Journal, 25
R. Shaw, A. Fay, M. Puthenveedu, M. Zastrow, Y. Jan, L. Jan (2007)
Microtubule Plus-End-Tracking Proteins Target Gap Junctions Directly from the Cell Interior to Adherens JunctionsCell, 133
L. Munaron (2002)
Calcium signalling and control of cell proliferation by tyrosine kinase receptors (review).International journal of molecular medicine, 10 6
K. Ohta, R. Graf, G. Rosner, W. Heiss (1997)
Profiles of Cortical Tissue Depolarization in Cat Focal Cerebral Ischemia in Relation to Calcium Ion Homeostasis and Nitric Oxide ProductionJournal of Cerebral Blood Flow & Metabolism, 17
D. Granger, R. Korthuis (1995)
Physiologic mechanisms of postischemic tissue injury.Annual review of physiology, 57
L. Tao, A. Harris (2007)
2-Aminoethoxydiphenyl Borate Directly Inhibits Channels Composed of Connexin26 and/or Connexin32Molecular Pharmacology, 71
M. Kanemitsu, Wei Jiang, Wafter Eckhart (1998)
Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 9 1
G. Zipfel, J. Lee, D. Choi (1999)
Reducing calcium overload in the ischemic brain.The New England journal of medicine, 341 20
E. Trexler, F. Bukauskas, M. Bennett, T. Bargiello, V. Verselis (1999)
Rapid and Direct Effects of pH on Connexins Revealed by the Connexin46 Hemichannel PreparationThe Journal of General Physiology, 113
H. Li, Tai-feng Liu, A. Lazrak, A. Lazrak, C. Peracchia, G. Goldberg, P. Lampe, Ross Johnson (1996)
Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cellsThe Journal of Cell Biology, 134
R. Malchow, Haohua Qian, Harris Ripps (1994)
A novel action of quinine and quinidine on the membrane conductance of neurons from the vertebrate retinaThe Journal of General Physiology, 104
M. Srinivas, J. Kronengold, F. Bukauskas, T. Bargiello, V. Verselis (2005)
Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels.Biophysical journal, 88 3
A Bruno, J Biller, HP Adams, WR Clarke, RF Woolson, LS Williams, MD Hansen (1999)
Acute blood glucose level and outcome from ischemic stroke. Trial of ORG 10172 in Acute Stroke Treatment (TOAST) investigatorsNeurology, 52
X. Bao, G. Altenberg, L. Reuss (2004)
Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation.American journal of physiology. Cell physiology, 286 3
T. Nakase, G. Söhl, M. Theis, K. Willecke, C. Naus (2004)
Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes.The American journal of pathology, 164 6
Juan Sáez, Juan Sáez, A. Nairn, A. Czernik, Glenn Fishman, D. Spray, Elliot Hertzberg (1997)
Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions.Journal of molecular and cellular cardiology, 29 8
A. Hofer, R. Dermietzel (1998)
Visualization and functional blocking of gap junction hemichannels (connexons) with antibodies against external loop domains in astrocytesGlia, 24
Guilherme Essenfelder, R. Bruzzone, J. Lamartine, A. Charollais, C. Blanchet‐Bardon, M. Barbe, P. Meda, G. Waksman (2004)
Connexin30 mutations responsible for hidrotic ectodermal dysplasia cause abnormal hemichannel activity.Human molecular genetics, 13 16
B. Jedamzik, I. Marten, A. Ngezahayo, A. Ernst, H. Kolb (2000)
Regulation of Lens rCx46-formed Hemichannels by Activation of Protein Kinase C, External Ca2+ and ProtonsThe Journal of Membrane Biology, 173
K. Braet, W. Vandamme, Patricia Martin, W. Evans, L. Leybaert (2003)
Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26.Cell calcium, 33 1
E. Vuyst, E. Decrock, M. Bock, H. Yamasaki, C. Naus, W. Evans, L. Leybaert (2006)
Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor.Molecular biology of the cell, 18 1
U. Dirnagl, C. Iadecola, M. Moskowitz (1999)
Pathobiology of ischaemic stroke: an integrated viewTrends in Neurosciences, 22
J. Sáez, A. Martínez, M. Brañes, H. González (1998)
Regulation of gap junctions by protein phosphorylation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 31 5
L. Vergara, X. Bao, M. Cooper, E. Bello‐Reuss, L. Reuss (2003)
Gap-junctional Hemichannels Are Activated by ATP Depletion in Human Renal Proximal Tubule CellsThe Journal of Membrane Biology, 196
Derek Beahm, James Hall (2002)
Hemichannel and junctional properties of connexin 50.Biophysical journal, 82 4
H. Kanter, J. Saffitz, E. Beyer (1992)
Cardiac myocytes express multiple gap junction proteins.Circulation research, 70 2
Z. Ye, Megan Wyeth, Selva Baltan-Tekkok, B. Ransom (2003)
Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate ReleaseThe Journal of Neuroscience, 23
Lisa Ebihara, E. Steiner (1993)
Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytesThe Journal of General Physiology, 102
S. Locovei, Junjie Wang, G. Dahl (2006)
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calciumFEBS Letters, 580
S. Locovei, Li Bao, G. Dahl (2006)
Pannexin 1 in erythrocytes: Function without a gap, 103
D. Paul, L. Ebihara, L. Takemoto, K. Swenson, D. Goodenough (1991)
Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytesThe Journal of Cell Biology, 115
Y. Panchin (2005)
Evolution of gap junction proteins – the pannexin alternativeJournal of Experimental Biology, 208
M. Murányi, C. Ding, Qingping He, Yanling Lin, Ping-An Li (2006)
Streptozotocin-induced diabetes causes astrocyte death after ischemia and reperfusion injury.Diabetes, 55 2
A Mottola, S Antoniotti, D Lovisolo, L Munaron (2005)
Regulation of noncapacitative calcium entry by arachidonic acid and nitric oxide in endothelial cellsFASEB J, 19
M. Romanello, P. D'andrea (2001)
Dual Mechanism of Intercellular Communication in HOBIT Osteoblastic Cells: A Role for Gap‐Junctional HemichannelsJournal of Bone and Mineral Research, 16
M. Globus, R. Prado, R. Busto (1995)
Ischemia-induced changes in extracellular levels of striatal cyclic GMP: role of nitric oxideNeuroReport, 6
T. White, D. Paul (1999)
Genetic diseases and gene knockouts reveal diverse connexin functions.Annual review of physiology, 61
(2002)
pH gating of Cx 43 - GFP hemichannels [ abstract ]
X. Bao, S. Lee, L. Reuss, G. Altenberg (2007)
Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKCProceedings of the National Academy of Sciences, 104
J. Vanslyke, L. Musil (2005)
Cytosolic stress reduces degradation of connexin43 internalized from the cell surface and enhances gap junction formation and function.Molecular biology of the cell, 16 11
Dooha Kim, Y. Kam, S. Koo, C. Joe (1999)
Gating Connexin 43 Channels Reconstituted in Lipid Vesicles by Mitogen-activated Protein Kinase Phosphorylation*The Journal of Biological Chemistry, 274
P. Lipton (1999)
Ischemic cell death in brain neurons.Physiological reviews, 79 4
Grace Liang, M. Miguel, J. Gómez-Hernandez, J. Glass, S. Scherer, M. Mintz, L. Barrio, K. Fischbeck (2005)
Severe neuropathy with leaky connexin32 hemichannelsAnnals of Neurology, 57
Agustín Martínez, J. Sáez (2000)
Regulation of astrocyte gap junctions by hypoxia–reoxygenationBrain Research Reviews, 32
S. DeVries, E. Schwartz (1992)
Hemi‐gap‐junction channels in solitary horizontal cells of the catfish retina.The Journal of Physiology, 445
V. Valiunas, R. Weingart (2000)
Electrical properties of gap junction hemichannels identified in transfected HeLa cellsPflügers Archiv, 440
Wei Wang, C. Oliva, Ge Li, A. Holmgren, C. Lillig, K. Kirk (2005)
Reversible Silencing of CFTR Chloride Channels by GlutathionylationThe Journal of General Physiology, 125
R. Bruzzone, R. Dermietzel (2006)
Structure and function of gap junctions in the developing brainCell and Tissue Research, 326
K. Braet, S. Aspeslagh, W. Vandamme, K. Willecke, Patricia Martin, W. Evans, L. Leybaert (2003)
Pharmacological sensitivity of ATP release triggered by photoliberation of inositol‐1,4,5‐trisphosphate and zero extracellular calcium in brain endothelial cellsJournal of Cellular Physiology, 197
In vitro and in vivo studies support the involvement of connexin 43-based cell-cell channels and hemichannels in cell death propagation induced by ischemia-reperfusion. In this context, open connexin hemichannels in the plasma membrane have been proposed to act as accelerators of cell death. Progress on the mechanisms underlying the cell permeabilization induced by ischemia-reperfusion reveals the involvement of several factors leading to an augmented open probability and increased number of hemichannels on the cell surface. While open probability can be increased by a reduction in extracellular concentration of divalent cations and changes in covalent modifications of connexin 43 (oxidation and phosphorylation), increase in number of hemichannels requires an elevation of the intracellular free Ca2+ concentration. Reversal of connexin 43 redox changes and membrane permeabilization can be induced by intracellular, but not extracellular, reducing agents, suggesting a cytoplasmic localization of the redox sensor(s). In agreement, hemichannels formed by connexin 45, which lacks cytoplasmic cysteines, or by connexin 43 with its C-terminal domain truncated to remove its cysteines are insensitive to reducing agents. Although further studies are required for a precise localization of the redox sensor of connexin 43 hemichannels, modulation of the redox potential is proposed as a target for the design of pharmacological tools to reduce cell death induced by ischemia-reperfusion in connexin 43-expressing cells.
The Journal of Membrane Biology – Springer Journals
Published: Aug 20, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.