Clin Pharmacokinet (2018) 57:739–748 https://doi.org/10.1007/s40262-017-0592-7 ORIGINAL RESEARCH ARTICLE Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy 1,2,3 1,2,3 4,5 1,2,3 • • • • Sophie Peigne ´ Ste ´phanie Chhun Michel Tod Elisabeth Rey 1,2,3 1,2,3 1,2,3 • • • Christelle Rodrigues Catherine Chiron Ge ´rard Pons 1,2,3,6,7 Vincent Jullien Published online: 17 August 2017 Springer International Publishing AG 2017 Abstract and apparent volume of distribution (V /F) of stiripentol Aim The aim of this study was to describe the pharma- were related to body weight by allometric equations. A cokinetics of stiripentol in children with Dravet syndrome dose-dependent non-linearity was also observed with an and to determine the concentrations of stiripentol achieved allometric model relating CL/F to the weight-normalised in this population for the usual 25 mg/kg twice-daily dose. dose. Mean population estimates (% inter-individual vari- Methods Thirty-ﬁve children with epilepsy were included ability) were 4.2 L/h (21%) for CL/F and 82 L (25%) for in a prospective population pharmacokinetic study (using V /F. The AUC of stiripentol increased by 300% when MONOLIX software). Four blood samples were drawn per body weight increased from 10 to 70 kg.
Clinical Pharmacokinetics – Springer Journals
Published: Aug 17, 2017
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