Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy

Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated... Clin Pharmacokinet (2018) 57:739–748 https://doi.org/10.1007/s40262-017-0592-7 ORIGINAL RESEARCH ARTICLE Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy 1,2,3 1,2,3 4,5 1,2,3 • • • • Sophie Peigne ´ Ste ´phanie Chhun Michel Tod Elisabeth Rey 1,2,3 1,2,3 1,2,3 • • • Christelle Rodrigues Catherine Chiron Ge ´rard Pons 1,2,3,6,7 Vincent Jullien Published online: 17 August 2017 Springer International Publishing AG 2017 Abstract and apparent volume of distribution (V /F) of stiripentol Aim The aim of this study was to describe the pharma- were related to body weight by allometric equations. A cokinetics of stiripentol in children with Dravet syndrome dose-dependent non-linearity was also observed with an and to determine the concentrations of stiripentol achieved allometric model relating CL/F to the weight-normalised in this population for the usual 25 mg/kg twice-daily dose. dose. Mean population estimates (% inter-individual vari- Methods Thirty-five children with epilepsy were included ability) were 4.2 L/h (21%) for CL/F and 82 L (25%) for in a prospective population pharmacokinetic study (using V /F. The AUC of stiripentol increased by 300% when MONOLIX software). Four blood samples were drawn per body weight increased from 10 to 70 kg. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Pharmacokinetics Springer Journals

Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
ISSN
0312-5963
eISSN
1179-1926
D.O.I.
10.1007/s40262-017-0592-7
Publisher site
See Article on Publisher Site

Abstract

Clin Pharmacokinet (2018) 57:739–748 https://doi.org/10.1007/s40262-017-0592-7 ORIGINAL RESEARCH ARTICLE Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy 1,2,3 1,2,3 4,5 1,2,3 • • • • Sophie Peigne ´ Ste ´phanie Chhun Michel Tod Elisabeth Rey 1,2,3 1,2,3 1,2,3 • • • Christelle Rodrigues Catherine Chiron Ge ´rard Pons 1,2,3,6,7 Vincent Jullien Published online: 17 August 2017 Springer International Publishing AG 2017 Abstract and apparent volume of distribution (V /F) of stiripentol Aim The aim of this study was to describe the pharma- were related to body weight by allometric equations. A cokinetics of stiripentol in children with Dravet syndrome dose-dependent non-linearity was also observed with an and to determine the concentrations of stiripentol achieved allometric model relating CL/F to the weight-normalised in this population for the usual 25 mg/kg twice-daily dose. dose. Mean population estimates (% inter-individual vari- Methods Thirty-five children with epilepsy were included ability) were 4.2 L/h (21%) for CL/F and 82 L (25%) for in a prospective population pharmacokinetic study (using V /F. The AUC of stiripentol increased by 300% when MONOLIX software). Four blood samples were drawn per body weight increased from 10 to 70 kg.

Journal

Clinical PharmacokineticsSpringer Journals

Published: Aug 17, 2017

References

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