Eur J Clin Pharmacol (2017) 73:1111–1119 DOI 10.1007/s00228-017-2279-2 PHARMACOKINETICS AND DISPOSITION Population pharmacokinetics of cyclosporine A in Japanese renal transplant patients: comprehensive analysis in a single center 1 2 1 1 Akira Okada & Hidetaka Ushigome & Misaki Kanamori & Aya Morikochi & 3 4 5 6 Hidefumi Kasai & Tadashi Kosaka & Takatoshi Kokuhu & Asako Nishimura & 6 1 2 1 Nobuhito Shibata & Keizo Fukushima & Norio Yoshimura & Nobuyuki Sugioka Received: 17 March 2017 /Accepted: 2 June 2017 /Published online: 15 June 2017 Springer-Verlag GmbH Germany 2017 Abstract comprehensively estimated, including preoperative PK Purpose Cyclosporine A (CyA), a potent immunosuppressive parameters. agent used in renal transplantation, has a narrow therapeutic Results A two-compartment model with first-order absorption window and a large variability in blood concentrations. This and absorption lag time was selected in this study. Aspartate study aimed to develop a population pharmacokinetic (PPK) aminotransferase, body surface area (BSA), pretransplant area model of CyA in living-donor renal transplant patients at a under the whole blood concentration–time curve/dose, and single center and identify factors influencing CyA pharmaco- postoperative days were identified as the covariates on oral kinetics (PK). clearance. BSA was selected as a covariate of
European Journal of Clinical Pharmacology – Springer Journals
Published: Jun 15, 2017
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