Polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile seizures: a meta-analysis

Polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile... The aim of the current study was to clarify the role of four common genetic polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile seizures (FS) by means of meta-analyses. We searched for studies published until February 2018 using ISI Web of Science, Pubmed, Wanfang, and Chinese National Knowledge Infrastructure databases. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using MetaAnalyst version Beta 3.13. Seventeen case-control studies were included for meta-analysis. For the IL-1B rs16944 polymorphism, the summary analysis of studies conducted among Caucasian populations showed a significant association in the CT+TT versus CC contrast (OR 1.434, 95% CI 1.153–1.785), while the pooled analysis for Asian populations yielded a significant estimate in the TT versus CC+CT comparison (OR 1.393, 95% CI 1.051–1.846). No association was observed between the IL-1B rs1143627, IL-1B rs1143634, and IL-1A rs1800587 polymorphisms and FS risk. Sensitivity analyses excluding studies showing deviation from Hardy-Weinberg equilibrium did not alter conclu- sions. The findings of our meta-analysis suggest that the IL-1B rs16944 polymorphism may be an important genetic determinant for FS in Caucasian and Asian populations. . . Keywords Febrile seizures Interleukin-1 Meta-analysis Introduction and second-degree relatives of children with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurological Sciences Springer Journals

Polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile seizures: a meta-analysis

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Publisher
Springer Milan
Copyright
Copyright © 2018 by Springer-Verlag Italia S.r.l., part of Springer Nature
Subject
Medicine & Public Health; Neurology; Neuroradiology; Neurosurgery; Psychiatry
ISSN
1590-1874
eISSN
1590-3478
D.O.I.
10.1007/s10072-018-3449-4
Publisher site
See Article on Publisher Site

Abstract

The aim of the current study was to clarify the role of four common genetic polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile seizures (FS) by means of meta-analyses. We searched for studies published until February 2018 using ISI Web of Science, Pubmed, Wanfang, and Chinese National Knowledge Infrastructure databases. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using MetaAnalyst version Beta 3.13. Seventeen case-control studies were included for meta-analysis. For the IL-1B rs16944 polymorphism, the summary analysis of studies conducted among Caucasian populations showed a significant association in the CT+TT versus CC contrast (OR 1.434, 95% CI 1.153–1.785), while the pooled analysis for Asian populations yielded a significant estimate in the TT versus CC+CT comparison (OR 1.393, 95% CI 1.051–1.846). No association was observed between the IL-1B rs1143627, IL-1B rs1143634, and IL-1A rs1800587 polymorphisms and FS risk. Sensitivity analyses excluding studies showing deviation from Hardy-Weinberg equilibrium did not alter conclu- sions. The findings of our meta-analysis suggest that the IL-1B rs16944 polymorphism may be an important genetic determinant for FS in Caucasian and Asian populations. . . Keywords Febrile seizures Interleukin-1 Meta-analysis Introduction and second-degree relatives of children with

Journal

Neurological SciencesSpringer Journals

Published: May 28, 2018

References

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