Polymorphisms in equine immune response genes and their associations with infections

Polymorphisms in equine immune response genes and their associations with infections Polymorphic markers identified in the horse genes encoding the interleukin 12 p40 subunit, interferon γ, tumor necrosis factor receptor 1, and inducible nitric oxide synthase were identified and tested, along with additional markers, for associations with two important horse infections: Rhodococcus equi and Lawsonia intracellularis. Eight immune response-related and 14 microsatellite loci covering 12 out of 31 equine autosomes were used for the association analysis. Markers located on horse Chromosomes Eca10 and 15 were significantly associated with the presence of high numbers of R. equi in transtracheal aspirates. Significant associations of markers located on Eca9, 15, and 21 with fecal shedding of Lawsonia intracellularis were found. Marginal associations with tumor necrosis factor α, interferon γ, and other genes suggested that variations in immune response-related genes could underlie the phenotypic variation observed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

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Publisher
Springer Journals
Copyright
Copyright © 2004 by Springer-Verlag
Subject
Life Sciences; Anatomy; Cell Biology; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-004-2356-6
Publisher site
See Article on Publisher Site

Abstract

Polymorphic markers identified in the horse genes encoding the interleukin 12 p40 subunit, interferon γ, tumor necrosis factor receptor 1, and inducible nitric oxide synthase were identified and tested, along with additional markers, for associations with two important horse infections: Rhodococcus equi and Lawsonia intracellularis. Eight immune response-related and 14 microsatellite loci covering 12 out of 31 equine autosomes were used for the association analysis. Markers located on horse Chromosomes Eca10 and 15 were significantly associated with the presence of high numbers of R. equi in transtracheal aspirates. Significant associations of markers located on Eca9, 15, and 21 with fecal shedding of Lawsonia intracellularis were found. Marginal associations with tumor necrosis factor α, interferon γ, and other genes suggested that variations in immune response-related genes could underlie the phenotypic variation observed.

Journal

Mammalian GenomeSpringer Journals

Published: Jan 1, 2004

References

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