Although the rabies virus P and M genes, encoding the viral phosphoprotein and matrix protein respectively, have been characterised for a few laboratory-adapted strains, there is essentially no information on the variability of these two genes in wild-type rabies viruses. In this study rabies viruses, responsible for epizootics in different wildlife species in three geographically distinct areas of North America, have been characterised at the P and M gene loci. These data reveal that the M gene and its encoded product are much more conserved than the P gene and its encoded phosphoprotein. The latter product harbors two variable domains which contribute to different hydropathy profiles for this protein for each of the rabies virus strains studied. Phylogenetic analysis of the nucleotide sequences generated in this study, together with data generated previously on the N and G genes of these rabies virus strains, indicated that similar evolutionary relationships are predicted regardless of the portion of the viral genome targeted.
Archives of Virology – Springer Journals
Published: May 1, 1997
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera