Polymorphism in the Human Serotonin Transporter Gene in Endogenous Psychoses

Polymorphism in the Human Serotonin Transporter Gene in Endogenous Psychoses Associations of the VNTR-17 and 5-HTTLPR polymorphisms of the serotonin transporter gene with affective disorders, including depression, have been found. These polymorphisms were analyzed in two groups of Russian probands: patients with endogenous psychoses and control individuals without mental disorders (423 and 277 persons, respectively). No associations were found between VNTR-17 genotypes or alleles and the diseases. However, the frequency of10/10 (VNTR-17) homozygotes increased with age in both patients and healthy persons. The results of the analysis of the 5-HTTLPR polymorphism suggest an association of the short (s) allele of the 5-HTTLPR polymorphism with schizophrenia and schizoaffective psychoses, but not with affective disorders. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Polymorphism in the Human Serotonin Transporter Gene in Endogenous Psychoses

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Kluwer Academic Publishers-Plenum Publishers
Copyright © 2000 by MAIK “Nauka/Interperiodica”
Biomedicine; Human Genetics
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