Polymorphism (353)R>Q of gene of blood clotting factor VII and plasma hemostasis

Polymorphism (353)R>Q of gene of blood clotting factor VII and plasma hemostasis A comparative estimation was conducted to assess the prevalence of genotypes and alleles of the R>Q(353) polymorphism of the coagulation factor FVII gene between a group of the Russian adolescents with essential arterial hypertension and a group of Russian adolescents without such health problems. The RR genotype was diagnosed in 55 adolescents (75.34%) of the control group and in 99 adolescents (84.61%) of the adolescents suffering from essential arterial hypertension (χ2 = 1.949, p = 0.163). The R allele frequency was, respectively, 85.62 and 91.88% (χ2 = 3.110, p = 0.078). The role of the FVII gene in the determination of the F7 plasma activity was defined in adolescents with essential arterial hypertension and holders of different alleles. Holders of the R allele had significantly higher activity of coagulation factor F7 (97.66 ± 15.48 against 83.37 ± 15.16, p = 0.002), factor F2 (107.45 ± 6.03 against 103.75 ± 6.81, p = 0.023), and antithrombin III (104.47 ± 15.54% against 95.87 ± 11.30%, p = 0.024). than holders of the Q allele. This relationship was not found in adolescents of the control group. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Polymorphism (353)R>Q of gene of blood clotting factor VII and plasma hemostasis

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Publisher
Pleiades Publishing
Copyright
Copyright © 2016 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795415120030
Publisher site
See Article on Publisher Site

Abstract

A comparative estimation was conducted to assess the prevalence of genotypes and alleles of the R>Q(353) polymorphism of the coagulation factor FVII gene between a group of the Russian adolescents with essential arterial hypertension and a group of Russian adolescents without such health problems. The RR genotype was diagnosed in 55 adolescents (75.34%) of the control group and in 99 adolescents (84.61%) of the adolescents suffering from essential arterial hypertension (χ2 = 1.949, p = 0.163). The R allele frequency was, respectively, 85.62 and 91.88% (χ2 = 3.110, p = 0.078). The role of the FVII gene in the determination of the F7 plasma activity was defined in adolescents with essential arterial hypertension and holders of different alleles. Holders of the R allele had significantly higher activity of coagulation factor F7 (97.66 ± 15.48 against 83.37 ± 15.16, p = 0.002), factor F2 (107.45 ± 6.03 against 103.75 ± 6.81, p = 0.023), and antithrombin III (104.47 ± 15.54% against 95.87 ± 11.30%, p = 0.024). than holders of the Q allele. This relationship was not found in adolescents of the control group.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Mar 31, 2016

References

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