Polymorphisms of the genes for angiotensin-converting enzyme (ACE) and angiotensinogen, the proteins of the renin–angiotensin system (RAS), were tested for association with the polymetabolic syndrome (PMS) and non-insulin-dependent diabetes mellitus (NIDDM) in the Moscow population. The insertional (I) allele and the IIgenotypeof the ACE gene proved to be associated with PMS. A significant difference in allele and genotype frequency distributions of the (CA) n microsatellite of the 3"-untranslated exon of the angiotensinogen gene was revealed between randomly sampled individuals and patients with PMS and IDDM from the Moscow population.
Russian Journal of Genetics – Springer Journals
Published: Oct 16, 2004
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