Polymorphic Transformation of Indomethacin during Hot Melt Extrusion Granulation: Process and Dissolution Control

Polymorphic Transformation of Indomethacin during Hot Melt Extrusion Granulation: Process and... Pharm Res (2018) 35: 140 https://doi.org/10.1007/s11095-017-2325-x RESEARCH PAPER Polymorphic Transformation of Indomethacin during Hot Melt Extrusion Granulation: Process and Dissolution Control 1 1 1 2 3 Ting Xu & Kajalajit Nahar & Rutesh Dave & Simon Bates & Kenneth Morris Received: 6 October 2017 /Accepted: 3 December 2017 /Published online: 10 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2017 Conclusions By determining the conditions that either pre- ABSTRACT Purpose To study and elucidate the effect of the intensity and vent or facilitate process induced transformations of IMC duration of processing stresses on the possible solid-state polymorphs during melt granulation, a design space was de- changes during a hot melt extrusion granulation process. veloped to control the polymorph present in the resulting Methods Blends of α-indomethacin and PEG 3350 (w/w 4:1) granules. This represents the conditions necessary to balance were granulated using various screw sizes/designs on the melt the thermodynamic relationships between the polymorphs of extruder under different temperature regimes. Differential the IMC system and the kinetics of the possible transforma- Scanning Calorimetry and X-ray Powder Diffraction were tions as a function of the processing stresses. employed for characterization. The dissolution behavior of . . the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Polymorphic Transformation of Indomethacin during Hot Melt Extrusion Granulation: Process and Dissolution Control

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
D.O.I.
10.1007/s11095-017-2325-x
Publisher site
See Article on Publisher Site

Abstract

Pharm Res (2018) 35: 140 https://doi.org/10.1007/s11095-017-2325-x RESEARCH PAPER Polymorphic Transformation of Indomethacin during Hot Melt Extrusion Granulation: Process and Dissolution Control 1 1 1 2 3 Ting Xu & Kajalajit Nahar & Rutesh Dave & Simon Bates & Kenneth Morris Received: 6 October 2017 /Accepted: 3 December 2017 /Published online: 10 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2017 Conclusions By determining the conditions that either pre- ABSTRACT Purpose To study and elucidate the effect of the intensity and vent or facilitate process induced transformations of IMC duration of processing stresses on the possible solid-state polymorphs during melt granulation, a design space was de- changes during a hot melt extrusion granulation process. veloped to control the polymorph present in the resulting Methods Blends of α-indomethacin and PEG 3350 (w/w 4:1) granules. This represents the conditions necessary to balance were granulated using various screw sizes/designs on the melt the thermodynamic relationships between the polymorphs of extruder under different temperature regimes. Differential the IMC system and the kinetics of the possible transforma- Scanning Calorimetry and X-ray Powder Diffraction were tions as a function of the processing stresses. employed for characterization. The dissolution behavior of . . the

Journal

Pharmaceutical ResearchSpringer Journals

Published: May 10, 2018

References

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