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P. Lysaker, M. Bell, E. Kaplan, T. Greig, G. Bryson (1999)
Personality and psychopathology in schizophrenia: the association between personality traits and symptoms.Psychiatry, 62 1
(2004)
An Associative Study of DRD4 Gene Polymorphisms in Promoter Region and Clinical Features of Schizophrenic Patients
F.B. Berezin, M.P. Miroshnikov, R.V. Rozhanets (1976)
Metodika mnogostoronnego issledovaniya lichnosti
V.M. Rusalov (1987)
A New Adaptation of the Eysenck Personality InventoryPsikhol. Zh., 8
A. Laurent, C. Gilvarry, A. Russell, R. Murray (2002)
Personality dimensions and neuropsychological performance in first-degree relatives of patients with schizophrenia and affective psychosisSchizophrenia Research, 55
K. Lakatos, Z. Nemoda, I. Tóth, Z. Rónai, K. Ney, M. Szekely, J. Gervai (2002)
Further evidence for the role of the dopamine D4 receptor (DRD4) gene in attachment disorganization: interaction of the exon III 48-bp repeat and the −521 C/T promoter polymorphismsMolecular Psychiatry, 7
M. Ritsner, H. Farkas, Anatoly Gibel (2003)
Satisfaction With Quality of Life Varies With Temperament Types of Patients With SchizophreniaThe Journal of Nervous and Mental Disease, 191
R. Ebstein, Olga Novick, R. Umansky, B. Priel, Y. Osher, Darren Blaine, E. Bennett, L. Nemanov, M. Katz, R. Belmaker (1996)
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty SeekingNature Genetics, 12
J. Os, P. Jones (2001)
Neuroticism as a risk factor for schizophreniaPsychological Medicine, 31
J. Schinka, E. Letsch, Fiona Crawford (2002)
DRD4 and novelty seeking: results of meta-analyses.American journal of medical genetics, 114 6
J. Ekelund, J. Suhonen, M. Järvelin, Leena Peltonen, Dirk Lichtermann (2001)
No association of the −521 C/T polymorphism in the promoter of DRD4 with novelty seekingMolecular Psychiatry, 6
(2002)
DRD 4 and Novelty Seeking : Results of Meta - Analyses , Am
Z. Rónai, A. Székely, Z. Nemoda, K. Lakatos, J. Gervai, Mária Staub, M. Sasvári-Székely (2001)
Association between Novelty Seeking and the −521 C/T polymorphism in the promoter region of the DRD4 geneMolecular Psychiatry, 6
Y. Okuyama, H. Ishiguro, M. Nankai, H. Shibuya, A. Watanabe, T. Arinami (2000)
Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality traitMolecular Psychiatry, 5
E. Bookman, R. Taylor, L. Adams-Campbell, R. Kittles (2002)
DRD4 promoter SNPs and gender effects on Extraversion in African AmericansMolecular Psychiatry, 7
(1987)
A New Adaptation of the Eysenck Personality Inventory, Psikhol
C. Cloninger (1987)
A systematic method for clinical description and classification of personality variants. A proposal.Archives of general psychiatry, 44 6
(1976)
Metodika mnogostoronnego issledovaniya lichnosti (Method of Multidimensional Personality Assessment)
Heon-Jeong Lee, H. Lee, Yong-Ku Kim, Seung-hyun Kim, L. Kim, Min-Soo Lee, S. Joe, I. Jung, K. Suh, Sangduk Kim (2003)
Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female populationAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 118B
A. Strobel, F. Spinath, A. Angleitner, R. Riemann, K. Lesch (2003)
Lack of Association between Polymorphisms of the Dopamine D4 Receptor Gene and PersonalityNeuropsychobiology, 47
(1996)
Exon III Polymorphism Associated with the Human Personality Trait of Novelty Seek
Z. Rónai, E. Szántai, R. Szmola, Z. Nemoda, A. Székely, J. Gervai, A. Guttman, M. Sasvári-Székely (2004)
A novel A/G SNP in the −615th position of the dopamine D4 receptor promoter region as a source of misgenotyping of the −616 C/G SNPAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 126B
H. Mitsuyasu, Hidetoshi Ozawa, Y. Takeda, Y. Fukumaki (1999)
Novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) geneJournal of Human Genetics, 44
The dopamine receptor gene D4 is a highly polymorphic gene, which, according to a number of studies, is associated with the personality traits characterizing human activity. Earlier, a VNTR polymorphic marker in exon 3 and single-nucleotide polymorphism in the promoter region were shown to be associated with novelty seeking. However, these results were not supported by all subsequent studies, which suggest a possible effect of other polymorphic regions of this gene. The aim of the present work was studying the effect of gene DRD4 on activity-related human personality traits in Russians, using in association analysis three polymorphic markers of this gene (−809 G/A, −616 C/G, and −521 C/T) and psychological traits assessed by various tests. Genotyping and psychological examination were conducted in 220 mentally healthy subjects (131 individuals lacking hereditary load of psychic diseases and 89 relatives of patients with psychoses). In Russians, allele frequencies of all markers proved to have no significant difference from the corresponding estimates for European populations. The markers examined were in linkage equilibrium. We have found a significant contribution of genotypes −521 C/T and −809 G/A to the expression of extraversion (Eysenck Personality Inventory (EPI), P = 0.0016) and variation of scores of the Social Introversion scale (Minnesota Multiphase Personality Inventory (MMPI), P = 0.0085). Genotypes −521 C/T and −616 C/G had a joint effect on scores on the Hypomania scale (P = 0.04), while their effect on extraversion was recorded as a trend (P = 0.054). Thus, the results of this study in general support the evidence by other authors showing association of polymorphism at the DRD4 gene promoter to personality traits. We have shown that the traits in question were mainly related to social activity. A reduction in social activity is associated largely with the T(−521 C/T) allele, characterized by low transcription rate.
Russian Journal of Genetics – Springer Journals
Published: Aug 9, 2005
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