1022-7954/01/3705- $25.00 © 2001
Russian Journal of Genetics, Vol. 37, No. 5, 2001, pp. 584–586. Translated from Genetika, Vol. 37, No. 5, 2001, pp. 712–715.
Original Russian Text Copyright © 2001 by Miloserdova, Slominsky, Tarskaya, Sorensen, Spitsyn, Limborskaya.
Yakuts (the Sakha people) are the second in popula-
tion size among all indigenous ethnoses of Siberia.
From the viewpoint of classical anthropology, Yakuts
belong to the Central Asian anthropological type. His-
torically and ethnographically, Yakuts are divided into
three groups: Central Yakuts, Vilyui Yakuts, and deer-
breeding Yakuts. Large-scale population genetic studies
in 11 regional Yakut populations revealed an appreciable
heterogeneity of the Yakut ethnos and a substantial con-
tribution of Central Asian and Baikal populations to the
formation of Yakuts. The Arctic anthropological compo-
nent was detected in Yakuts from the northeastern
regions of the Sakha Republic .
The total Yakut population was compared with eth-
noses from the adjacent regions with respect to ﬁve
independent loci (14 alleles). The result showed that
Yakuts are most closely related to Evenks and, to a
lesser extent, to western and eastern Buryats and Mon-
We examined Yakuts from the population of the
Megino-Kangalakskii raion, the central group of the
total ethnos. Based on the population genetic data, this
group is pooled together with the largest Yakut popula-
tions of the adjacent regions (the Aldanskii and Kob-
yaiskii raions and the right bank of the river Vilyui).
Thus, we studied the most representative and typical
population of the Yakut people.
The total Yakut population is characterized by a low
incidence of cardiovascular disorders , which can be
attributed to speciﬁc genetic features, mode of life, and
feeding habits of Yakuts.
Since disorders of the cardiovascular system are
rather common, the role of genetic factors in their
development has come to be extensively studied over
the recent years. An important role is ascribed to
changes in hemodynamics and blood pressure. Many
studies showed that the renin–angiotensin system
(RAS) occupies the central place in regulating the elec-
Polymorphic Markers of the Angiotensin
and Angiotensin-Converting Enzyme Genes in Yakuts:
A Lack of Association with Blood Pressure
O. V. Miloserdova
, P. A. Slominsky
, L. A. Tarskaya
, M. Sorensen
V. A. Spitsyn
, and S. A. Limborskaya
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia; e-mail: email@example.com
Institute of Health, Yakutsk, 677891 Sakha Republic, Russia
Department of Anthropology, Northwestern University, Evanston, Illinois, IL 27599 United States
Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, 115478 Russia
Received November 2, 2000
—Allele frequency distributions of the insertion/deletion (I/D) polymorphism of the angiotensin-con-
verting enzyme (ACE) gene and the M235T polymorphism of the angiotensinogen gene was studied in a ran-
dom sample of the indigenous population of the Sakha Republic. The allelic variants of these genes did not
showed an association with blood pressure in Yakuts.
Allele and genotype frequencies of the I/D polymorphism of the ACE gene in various populations
I D II ID DD
Yakut 0.66 0.34 0.442 0.435 0.123
Japanese (northern)  0.73 0.27 0.527 0.409 0.065
Japanese  0.63 0.37 0.41 0.447 0.143
Chinese  0.635 0.365 0.41 0.45 0.14
Russian (Moscow)  0.38 0.62 0.13 0.50 0.37
French  0.46 0.54 ND ND 0.27
Note: ND, not determined.