Polymeric hydrogels with memory effect for immobilization of binary drug combinations

Polymeric hydrogels with memory effect for immobilization of binary drug combinations Hydrogels with memory effect (imprinted hydrogels) with respect to a combination of cefotaxime and diclofenac were synthesized from 2-hydroxyethyl methacrylate and functional monomers (acrylic acid and N,N-dimethylacrylamide). The hydrogels obtained show increased ability to sorb cefotaxime and especially diclofenac. Prolonged release of cefotaxime was revealed, becoming more pronounced with an increase in the cefotaxime concentration in the solution from which it is sorbed with the hydrogel. The effect of selective sorption of diclofenac with imprinted hydrogels from the diclofenac-cefotaxime drug combination was discovered. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Applied Chemistry Springer Journals

Polymeric hydrogels with memory effect for immobilization of binary drug combinations

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Publisher
Springer US
Copyright
Copyright © 2013 by Pleiades Publishing, Ltd.
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
1070-4272
eISSN
1608-3296
D.O.I.
10.1134/S1070427213100182
Publisher site
See Article on Publisher Site

Abstract

Hydrogels with memory effect (imprinted hydrogels) with respect to a combination of cefotaxime and diclofenac were synthesized from 2-hydroxyethyl methacrylate and functional monomers (acrylic acid and N,N-dimethylacrylamide). The hydrogels obtained show increased ability to sorb cefotaxime and especially diclofenac. Prolonged release of cefotaxime was revealed, becoming more pronounced with an increase in the cefotaxime concentration in the solution from which it is sorbed with the hydrogel. The effect of selective sorption of diclofenac with imprinted hydrogels from the diclofenac-cefotaxime drug combination was discovered.

Journal

Russian Journal of Applied ChemistrySpringer Journals

Published: Dec 28, 2013

References

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