Russian Journal of Applied Chemistry, 2013, Vol. 86, No. 4, pp. 606−610.
Pleiades Publishing, Ltd., 2013.
Original Russian Text © R.Kh. Mudarisova, L.A. Badykova, G.A. Azamatova, R.M. Islamova, M.T. Aznabaev, 2013, published in Zhurnal Prikladnoi Khimii,
2013, Vol. 86, No. 4, pp. 650−654.
Polymeric Eye Films Based on Polyvinyl Alcohol
and Arabinogalactan with Levoﬂ oxacin
R. Kh. Mudarisova
, L. A. Badykova
, G. A. Azamatova
R. M. Islamova
, and M. T. Aznabaev
Institute of Organic Chemistry, Ural Scientiﬁ c Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russia
Bashkir State Medical University, Ufa, Bashkortostan, Russia
Bashkir State Agricultural University, Ufa, Bashkortostan, Russia
Received January 11, 2012
Abstract—Physicochemical methods were used to study the interaction of arabinogalactan from Siberian larch
with the antibacterial preparation levoﬂ oxacin. Polymeric eye ﬁ lms with controllable output of the medicinal
preparation were produced on the basis of an arabinogalactan–polyvinyl alcohol formulation. A high pharmaceuti-
cal activity of the new eye ﬁ lms was demonstrated.
Development and study of systems for directed
transport and controlled release of medicinal substances
from medicinal ﬁ lms is a topical area of modern
pharmacochemistry. Medicated ﬁ lms based on polymer
mixtures are rather promising in this regard. In particular,
they can be regarded as polymeric matrices for ﬁ xation
of medicinal preparations and prolongation of their
action in development of new medicated eye ﬁ lms
(MEFs). In ophthalmology, postoperative infection
still remains a problem. Instillation of medicinal
preparations is one of the most widely used methods
for antibiotic prophylaxis of these complications.
However, an important disadvantage of eye drops
is the fast absorption of a preparation by the mucous
eye membranes and its substantial loss with tears and
in winking . It has been conﬁ rmed that instillations
fail to create in the aqueous eye chamber the antibiotic
concentration necessary for suppressing the growth
of microorganisms and, therefore, cannot provide the
effective prophylaxis [2, 3]. Therefore, development and
application of medicated eye ﬁ lms is a rational solution
of the problem of prolongation and dosed delivery of
medicinal preparations into eye tissues.
The system of polyvinyl alcohol (PVA) and
arabinogalactan (AG) was studied as a polymeric support
in development of medicinal eye ﬁ lms. At present,
PVA and a natural polysaccharide arabinogalactan are
widely used in medicine. These supports are nontoxic
and biocompatible and make substantially more
prolonged the effect of medicinal preparations [4, 5].
Also, arabinogalactan exhibits a versatile biological
activity. All the arabinogalactans studied exert a
controlling inﬂ uence on the immune system and have
membranotropic properties, owing to which they can
be used to enhance the absorption of other medicinal
preparations characterized by low bioavailability.
AG also has an antimicrobial effect on some bacteria,
stimulates the reticuloendothelial system, and enhances
the phagocytic activity of macrophages . However,
AG itself has no ﬁ lm-forming properties, and, therefore,
it was of indubitable interest to introduce AG into a ﬁ lm-
forming polymer widely used in medicine, polyvinyl
alcohol. A system of this kind can enhance the therapeutic
effect of an immobilized medicinal preparation and is
biodegradable under its application conditions because
the polymers are water soluble.