Clin Res Cardiol (2017) 106:686–694 DOI 10.1007/s00392-017-1104-3 ORIGINAL PAPER Point-of-care testing of cardiac autonomic function for risk assessment in patients with suspected acute coronary syndromes 1 1 1 1 1 1 C. Eick · M. Duckheim · P. Groga-Bada · N. Klumpp · S. Mannes · C. S. Zuern · 1 2,3 2,3 M. Gawaz · K. D. Rizas · Axel Bauer Received: 28 September 2016 / Accepted: 8 March 2017 / Published online: 22 March 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract endpoints, respectively. DC was a highly significant predic- Background Impaired cardiac autonomic function has tor of both endpoints, yielding areas under the curve (AUC) been linked to adverse outcomes in patients with acute cor- of 0.784 (95% CI 0.714–0.854) and 0.781 (0.727–0.832) onary syndromes (ACS) but is not included in clinical risk (p < 0.001 for both), respectively. Implementing DC into models. This is the first study to investigate whether point- the GRACE-risk model leads to a significant increase of of-care testing of cardiac autonomic function by means the C-statistics from 0.788 (0.703–0.874) to 0.825 (0.750– of short-term deceleration capacity (DC) of heart rate 0.900; p < 0.01 for difference) and from 0.814 (0.759– improves risk assessment in patients with suspected ACS. 0.864) to 0.851 (0.808–0.889; p < 0.01 for
Zeitschrift für Kardiologie – Springer Journals
Published: Mar 22, 2017
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