Point-of-care testing of cardiac autonomic function for risk assessment in patients with suspected acute coronary syndromes

Point-of-care testing of cardiac autonomic function for risk assessment in patients with... Clin Res Cardiol (2017) 106:686–694 DOI 10.1007/s00392-017-1104-3 ORIGINAL PAPER Point-of-care testing of cardiac autonomic function for risk assessment in patients with suspected acute coronary syndromes 1 1 1 1 1 1 C. Eick  · M. Duckheim  · P. Groga-Bada  · N. Klumpp  · S. Mannes  · C. S. Zuern  · 1 2,3 2,3 M. Gawaz  · K. D. Rizas  · Axel Bauer   Received: 28 September 2016 / Accepted: 8 March 2017 / Published online: 22 March 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract endpoints, respectively. DC was a highly significant predic- Background Impaired cardiac autonomic function has tor of both endpoints, yielding areas under the curve (AUC) been linked to adverse outcomes in patients with acute cor- of 0.784 (95% CI 0.714–0.854) and 0.781 (0.727–0.832) onary syndromes (ACS) but is not included in clinical risk (p < 0.001 for both), respectively. Implementing DC into models. This is the first study to investigate whether point- the GRACE-risk model leads to a significant increase of of-care testing of cardiac autonomic function by means the C-statistics from 0.788 (0.703–0.874) to 0.825 (0.750– of short-term deceleration capacity (DC) of heart rate 0.900; p < 0.01 for difference) and from 0.814 (0.759– improves risk assessment in patients with suspected ACS. 0.864) to 0.851 (0.808–0.889; p < 0.01 for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Zeitschrift für Kardiologie Springer Journals

Point-of-care testing of cardiac autonomic function for risk assessment in patients with suspected acute coronary syndromes

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Cardiology
ISSN
0300-5860
eISSN
1861-0692
D.O.I.
10.1007/s00392-017-1104-3
Publisher site
See Article on Publisher Site

Abstract

Clin Res Cardiol (2017) 106:686–694 DOI 10.1007/s00392-017-1104-3 ORIGINAL PAPER Point-of-care testing of cardiac autonomic function for risk assessment in patients with suspected acute coronary syndromes 1 1 1 1 1 1 C. Eick  · M. Duckheim  · P. Groga-Bada  · N. Klumpp  · S. Mannes  · C. S. Zuern  · 1 2,3 2,3 M. Gawaz  · K. D. Rizas  · Axel Bauer   Received: 28 September 2016 / Accepted: 8 March 2017 / Published online: 22 March 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract endpoints, respectively. DC was a highly significant predic- Background Impaired cardiac autonomic function has tor of both endpoints, yielding areas under the curve (AUC) been linked to adverse outcomes in patients with acute cor- of 0.784 (95% CI 0.714–0.854) and 0.781 (0.727–0.832) onary syndromes (ACS) but is not included in clinical risk (p < 0.001 for both), respectively. Implementing DC into models. This is the first study to investigate whether point- the GRACE-risk model leads to a significant increase of of-care testing of cardiac autonomic function by means the C-statistics from 0.788 (0.703–0.874) to 0.825 (0.750– of short-term deceleration capacity (DC) of heart rate 0.900; p < 0.01 for difference) and from 0.814 (0.759– improves risk assessment in patients with suspected ACS. 0.864) to 0.851 (0.808–0.889; p < 0.01 for

Journal

Zeitschrift für KardiologieSpringer Journals

Published: Mar 22, 2017

References

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