Eur J Nucl Med Mol Imaging (2017) 44:1679–1681 DOI 10.1007/s00259-017-3754-9 EDITORIAL 1 1 1 1,2 Takuya Toyonaga & Kenji Hirata & Tohru Shiga & Tamaki Nagara Received: 2 June 2017 /Accepted: 5 June 2017 /Published online: 20 June 2017 Springer-Verlag GmbH Germany 2017 Hypoxia is one of the most important factors for exacerbating these subjects from the standpoints of treatment strategy [8, 9], malignancy, including brain tumors [1–3]. Hypoxia induces gene mutation , the methylation of DNA , and molec- radioresistance , chemoresistance , HRE-related gene ular mechanisms . They also performed imaging studies of transcription , and hypermethylation of tumor suppressor glioma [13, 14]. In the current study, we use FMISO to image tumor hypoxia genes , making tumor cells more aggressive. These phenom- ena interact with one another such that the entire set of mech- and focus on the correlation between hypoxia and the expres- anisms could be described as ‘Hypoxia Orchestra playing sion of HIF1α, CAIX VEGF, and Ang2. HIF1α and CAIX are Symphony Malignancy’. Of the above cascades, the correlation known as hypoxia markers, but the expression mechanisms are between hypoxia and HRE-related gene transcription has been totally different; it is even said that those
European Journal of Nuclear Medicine and Molecular Imaging – Springer Journals
Published: Jun 20, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera