Players of ‘hypoxia orchestra’ – what is the role of FMISO?

Players of ‘hypoxia orchestra’ – what is the role of FMISO? Eur J Nucl Med Mol Imaging (2017) 44:1679–1681 DOI 10.1007/s00259-017-3754-9 EDITORIAL 1 1 1 1,2 Takuya Toyonaga & Kenji Hirata & Tohru Shiga & Tamaki Nagara Received: 2 June 2017 /Accepted: 5 June 2017 /Published online: 20 June 2017 Springer-Verlag GmbH Germany 2017 Hypoxia is one of the most important factors for exacerbating these subjects from the standpoints of treatment strategy [8, 9], malignancy, including brain tumors [1–3]. Hypoxia induces gene mutation [10], the methylation of DNA [11], and molec- radioresistance [4], chemoresistance [5], HRE-related gene ular mechanisms [12]. They also performed imaging studies of transcription [6], and hypermethylation of tumor suppressor glioma [13, 14]. In the current study, we use FMISO to image tumor hypoxia genes [7], making tumor cells more aggressive. These phenom- ena interact with one another such that the entire set of mech- and focus on the correlation between hypoxia and the expres- anisms could be described as ‘Hypoxia Orchestra playing sion of HIF1α, CAIX VEGF, and Ang2. HIF1α and CAIX are Symphony Malignancy’. Of the above cascades, the correlation known as hypoxia markers, but the expression mechanisms are between hypoxia and HRE-related gene transcription has been totally different; it is even said that those http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Nuclear Medicine and Molecular Imaging Springer Journals

Players of ‘hypoxia orchestra’ – what is the role of FMISO?

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
ISSN
1619-7070
eISSN
1619-7089
D.O.I.
10.1007/s00259-017-3754-9
Publisher site
See Article on Publisher Site

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