Clin Oral Invest (2017) 21:2165–2172 DOI 10.1007/s00784-016-2004-z ORIGINAL ARTICLE Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study 1 1 2 1 1 Takuya Asaka & Noritaka Ohga & Yutaka Yamazaki & Jun Sato & Chiharu Satoh & Yoshimasa Kitagawa Received: 6 May 2016 /Accepted: 1 November 2016 /Published online: 11 November 2016 Springer-Verlag Berlin Heidelberg 2016 Abstract (P < 0.05). Multivariate logistic regression analysis revealed Objectives The aim of the present study was to evaluate the that risk factors and use of PRF were independent significant effectiveness of platelet-rich fibrin (PRF) as a wound-healing factors to relate to delayed recovery (P =0.02). accelerator in patients undergoing oral bisphosphonate thera- Conclusions Early epithelization was confirmed in all PRF py and requiring tooth extractions. patients. Thus, PRF may reduce the risk of delayed recovery Materials and methods A total of 102 patients were divided in patients undergoing oral bisphosphonate therapy. into a PRF group and control group. The patients received oral Clinical relevance PRF may be useful in preventing MRONJ bisphosphonate therapy for osteoporosis for an average of in patients receiving oral bisphosphonate (BP). 32 months. Blood was collected and
Clinical Oral Investigations – Springer Journals
Published: Nov 11, 2016
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