Platelet-Derived Growth Factor Subunit B Signaling Promotes Pericyte Migration in Response to Loud Sound in the Cochlear Stria Vascularis

Platelet-Derived Growth Factor Subunit B Signaling Promotes Pericyte Migration in Response to... JARO (2018) DOI: 10.1007/s10162-018-0670-z D 2018 Association for Research in Otolaryngology JARO Journal of the Association for Research in Otolaryngology Research Article Platelet-Derived Growth Factor Subunit B Signaling Promotes Pericyte Migration in Response to Loud Sound in the Cochlear Stria Vascularis 1 1 1 1 2 3 ZHIQIANG HOU, XIAOHAN WANG, JING CAI, JINHUI ZHANG, AHMED HASSAN, MANFRED AUER, AND XIAORUI SHI Oregon Hearing Research Center, Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, Portland, OR 97239, USA Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA Received: 15 December 2017; Accepted: 19 April 2018 ABSTRACT trusion is characterized by pericytes with a prominent triangular shape, or pericytes extending fine strands Normal blood supply to the cochlea is critical for to neighboring capillaries. The detachment is charac- hearing. Noise damages auditory sensory cells and has terized by pericyte detachment and movement away a marked effect on the microvasculature in the from vessels. We also found the sites of pericyte cochlear lateral wall. Pericytes in the stria vascularis migration highly associated with regions of vascular (strial pericytes) are particularly vulnerable and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the Association for Research in Otolaryngology Springer Journals

Platelet-Derived Growth Factor Subunit B Signaling Promotes Pericyte Migration in Response to Loud Sound in the Cochlear Stria Vascularis

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Publisher
Springer US
Copyright
Copyright © 2018 by Association for Research in Otolaryngology
Subject
Medicine & Public Health; Otorhinolaryngology; Neurosciences; Neurobiology
ISSN
1525-3961
eISSN
1438-7573
D.O.I.
10.1007/s10162-018-0670-z
Publisher site
See Article on Publisher Site

Abstract

JARO (2018) DOI: 10.1007/s10162-018-0670-z D 2018 Association for Research in Otolaryngology JARO Journal of the Association for Research in Otolaryngology Research Article Platelet-Derived Growth Factor Subunit B Signaling Promotes Pericyte Migration in Response to Loud Sound in the Cochlear Stria Vascularis 1 1 1 1 2 3 ZHIQIANG HOU, XIAOHAN WANG, JING CAI, JINHUI ZHANG, AHMED HASSAN, MANFRED AUER, AND XIAORUI SHI Oregon Hearing Research Center, Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, Portland, OR 97239, USA Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA Received: 15 December 2017; Accepted: 19 April 2018 ABSTRACT trusion is characterized by pericytes with a prominent triangular shape, or pericytes extending fine strands Normal blood supply to the cochlea is critical for to neighboring capillaries. The detachment is charac- hearing. Noise damages auditory sensory cells and has terized by pericyte detachment and movement away a marked effect on the microvasculature in the from vessels. We also found the sites of pericyte cochlear lateral wall. Pericytes in the stria vascularis migration highly associated with regions of vascular (strial pericytes) are particularly vulnerable and

Journal

Journal of the Association for Research in OtolaryngologySpringer Journals

Published: Jun 4, 2018

References

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