Cardiovasc Drugs Ther (2017) 31:269–279 DOI 10.1007/s10557-017-6737-y ORIGINAL ARTICLE Plasma Lipidome Analysis by Liquid Chromatography-High Resolution Mass Spectrometry and Ion Mobility of Hypertriglyceridemic Patients on Extended-Release Nicotinic Acid: a Pilot Study 1,2 1,2 1 2 Véronique Ferchaud-Roucher & Mikaël Croyal & Thomas Moyon & Yassine Zair & 1,2 1,2 Michel Krempf & Khadija Ouguerram Published online: 28 July 2017 Springer Science+Business Media, LLC 2017 Abstract revealed a significant increase of lysophosphatidylcholine Background Plasma high triacylglycerols and low HDL-C con- (LPC 20:5), a significant decrease of phosphatidylethanol- centration are associated with increased cardiovascular events. amine (PE 16:0/22:3) and sphingomyelin (SM d18:1/22:0) Extended-release nicotinic acid (ERN) was shown to reduce and a decrease of triacylglycerol (TG 16:0/16:1/18:2) after plasma triacylglycerols and total cholesterol but also to mark- ERN treatment. Analysis of these lipids in lipoproteins edly increase high-density lipoprotein-cholesterol (HDL-C). No showed an increase of LPC (20:5) in HDL, a decrease of PE data on the effect of ERN on different species of triacylglycerol, (16:0/22:3) in HDL and LDL, of SM (d18:1/22:0) in VLDL cholesteryl ester, and phospholipids are available. In this study, and LDL and of TG (16:0/16:1/18:2) in VLDL. we applied a nontargeted lipidomic approach to investigate the Conclusion
Cardiovascular Drugs and Therapy – Springer Journals
Published: Jul 28, 2017
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