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Huirong Xie, Haibin Wang, S. Tranguch, R. Iwamoto, E. Mekada, F. DeMayo, J. Lydon, S. Das, S. Dey (2007)
Maternal heparin-binding-EGF deficiency limits pregnancy success in miceProceedings of the National Academy of Sciences, 104
TJ Lynch, DW Bell, R Sordella, S Gurubhagavatula, RA Okimoto (2004)
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinibN Engl J Med, 350
Haibin Wang, Wen-ge Ma, Lovella Tejada, H. Zhang, J. Morrow, S. Das, S. Dey (2004)
Rescue of Female Infertility from the Loss of Cyclooxygenase-2 by Compensatory Up-regulation of Cyclooxygenase-1 Is a Function of Genetic Makeup*Journal of Biological Chemistry, 279
S. Das, H. Lim, J. Wang, B. Paria, M. BazDresch, S. Dey (1997)
Inappropriate expression of human transforming growth factor (TGF)-alpha in the uterus of transgenic mouse causes downregulation of TGF-beta receptors and delays the blastocyst-attachment reaction.Journal of molecular endocrinology, 18 3
Nili Jin, Jennifer Gilbert, R. Broaddus, F. DeMayo, Jae-Wook Jeong (2007)
Generation of a Mig‐6 conditional null allelegenesis, 45
M. Sibilia, Alexander Fleischmann, A. Behrens, L. Stingl, J. Carroll, F. Watt, J. Schlessinger, E. Wagner (2000)
The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor DevelopmentCell, 102
H Song, H Lim, BC Paria, H Matsumoto, LL Swift (2002)
Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for ‘on-time’ embryo implantation that directs subsequent developmentDevelopment, 129
A. Gillgrass, R. Cardiff, N. Sharan, S. Kannan, W. Muller (2003)
Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progressionOncogene, 22
X. Qian, L. Esteban, W. Vass, Cheerag Upadhyaya, A. Papageorge, Kate Yienger, J. Ward, D. Lowy, E. Santos (2000)
The Sos1 and Sos2 Ras‐specific exchange factors: differences in placental expression and signaling propertiesThe EMBO Journal, 19
J. Mudgett, Jixiang Ding, Lucia Guh-Siesel, N. Chartrain, Lu Yang, Shobhna Gopal, M. Shen (2000)
Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis.Proceedings of the National Academy of Sciences of the United States of America, 97 19
Haibin Wang, S. Dey (2006)
Roadmap to embryo implantation: clues from mouse modelsNature Reviews Genetics, 7
Karen Fitch, K. McGowan, C. Raamsdonk, H. Fuchs, Daekee Lee, A. Puech, Y. Hérault, D. Threadgill, M. Angelis, G. Barsh (2003)
Genetics of dark skin in mice.Genes & development, 17 2
Haengseok Song, H. Lim, B. Paria, H. Matsumoto, L. Swift, J. Morrow, J. Bonventre, S. Dey (2002)
Cytosolic phospholipase A2α deficiency is crucial for 'on-time' embryo implantation that directs subsequent developmentDevelopment, 129
V. Prévot, A. Lomniczi, G. Corfas, S. Ojeda (2005)
erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function.Endocrinology, 146 3
S. Das, H. Tsukamura, B. Paria, G. Andrews, S. Dey (1994)
Differential expression of epidermal growth factor receptor (EGF-R) gene and regulation of EGF-R bioactivity by progesterone and estrogen in the adult mouse uterus.Endocrinology, 134 2
N. Marozkina, S. Stiefel, H. Frierson, S. Parsons (2008)
MMTV‐EGF receptor transgene promotes preneoplastic conversion of multiple steroid hormone‐responsive tissuesJournal of Cellular Biochemistry, 103
Y. Hom, P. Young, J. Wiesen, P. Miettinen, R. Derynck, Z. Werb, G. Cunha (1998)
Uterine and Vaginal Organ Growth Requires Epidermal Growth Factor Receptor Signaling from Stroma.Endocrinology, 139 3
J. Park, Youqiang Su, M. Ariga, E. Law, S. Jin, M. Conti (2004)
EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory FollicleScience, 303
M. Saba-El-Leil, Francis Vella, Bertrand Vernay, L. Voisin, Lan Chen, N. Labrecque, S. Ang, S. Meloche (2003)
An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast developmentEMBO reports, 4
M. Sibilia, Erwin Wagner (1995)
Strain-dependent epithelial defects in mice lacking the EGF receptor.Science, 269 5221
R. Burney, S. Talbi, A. Hamilton, K. Vo, M. Nyegaard, C. Nezhat, B. Lessey, L. Giudice (2007)
Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis.Endocrinology, 148 8
A. Gratão, M. Dahlhoff, F. Sinowatz, E. Wolf, M. Schneider (2008)
Betacellulin Overexpression in the Mouse Ovary Leads to MAPK3/MAPK1 Hyperactivation and Reduces Litter Size by Impairing Fertilization1, 78
M. Hsieh, Daekee Lee, Sara Panigone, K. Horner, Ruby Chen, Alekos Theologis, David Lee, D. Threadgill, M. Conti (2006)
Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for OvulationMolecular and Cellular Biology, 27
Beverly Tong, Sanjoy Das, D. Threadgill, Terry Magnuson, Sudhansu Dey (1996)
Differential expression of the full-length and truncated forms of the epidermal growth factor receptor in the preimplantation mouse uterus and blastocyst.Endocrinology, 137 4
K. Fowler, F. Walker, Warren Alexander, M. Hibbs, E. Nice, R. Bohmer, G. Mann, C. Thumwood, Janine DANKSt, Runjen Chetty, A. Burgess, A. Dunn (1995)
A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.Proceedings of the National Academy of Sciences of the United States of America, 92
I. Krüger, M. Vollmer, D. Simmons, H. Elsässer, S. Philipsen, G. Suske (2007)
Sp1/Sp3 compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defectsDevelopmental Dynamics, 236
Seungchan Yang, S. Qu, Marianela Perez-Tores, A. Sawai, N. Rosen, D. Solit, C. Arteaga (2006)
Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors.Cancer research, 66 14
Zhong-Zhou Yang, O. Tschopp, M. Hemmings-Mieszczak, Jianhua Feng, D. Brodbeck, E. Perentes, B. Hemmings (2003)
Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth*Journal of Biological Chemistry, 278
K. Livak, Thomas Schmittgen (2001)
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.Methods, 25 4
Daniel Jones (2004)
Anticancer drugs: To the rescue?Nature Reviews Drug Discovery, 3
Reade Roberts, L. Min, M. Washington, S. Olsen, S. Settle, R. Coffey, D. Threadgill (2002)
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesisProceedings of the National Academy of Sciences of the United States of America, 99
D. Threadgill, Delia Yee, Argabin Matin, J. Nadeau, T. Magnuson (1997)
Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strainMammalian Genome, 8
M. McMullen, B. Cho, C. Yates, K. Mayo (2001)
Gonadal Pathologies in Transgenic Mice Expressing the Rat Inhibinα -Subunit.Endocrinology, 142 11
Epidermal growth factor receptor (EGFR) is a member of the ERBB family of receptor tyrosine kinases that has been shown to play an important developmental and physiologic role in many aspects of pregnancy. We have previously shown in mice that Egfr tm1Mag nullizygous placentas have fewer proliferative trophoblasts than wild-type and exhibit strain-specific defects in the spongiotrophoblast and labyrinth layers. In this study we used mice with the hypermorphic Egfr Dsk5 allele to study the effects of increased levels of EGFR signaling on placental development. On three genetic backgrounds, heterozygosity for Egfr Dsk5 resulted in larger placental size with a more prominent spongiotrophoblast layer and increased expression of glycogen cell-specific genes. The C3HeB/FeJ strain showed additional placental enlargement of Egfr Dsk5 homozygotes with a significant number of homozygous embryos dying prior to 15.5 days post-coitus (dpc). We also observed strain-specific subfertility in Egfr Dsk5 heterozygous females and pregnancy loss was dependent on maternal factors rather than embryo genotype. Higher levels of phospho-EGFR were detected in the uterus of Egfr Dsk5 heterozygotes but the structure of Egfr Dsk5 heterozygous nonpregnant uteri appeared similar to wild-type. Collectively, our results demonstrate that mice with increased levels of EGFR signaling exhibit an extensive level of genetic background-dependent phenotypic variability. In addition, EGFR promotes growth of the placental spongiotrophoblast layer in mice, and EGFR expressed in the uterine stroma may play an underappreciated role in preparation of the uterus for embryo implantation.
Mammalian Genome – Springer Journals
Published: May 23, 2009
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