Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance

Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill... Clin Pharmacokinet https://doi.org/10.1007/s40262-018-0682-1 ORIGINAL RESEARCH ARTICLE Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance 1,2 2,3 1,2 4 • • • • Agathe Be ´ranger Sihem Benaboud Saı ¨k Urien Florence Moulin 5 4 3 4 3 • • • • • Emmanuelle Bille Fabrice Lesage Yi Zheng Mathieu Genuini Ine `s Gana 4 2,3 1,2,3 2,4 • ´ • ´ • Sylvain Renolleau Deborah Hirt Jean-Marc Treluyer Mehdi Oualha Springer International Publishing AG, part of Springer Nature 2018 Abstract optimize dosing regimens in order to attain two PK targets: Background Critically ill children frequently display 50% fT and 100% fT . [MIC [MIC observed alterations of pharmacokinetic (PK) parameters, Results We included 50 children with a median (range) leading to a reduction in b-lactam concentrations. This postnatal age of 2.3 years (0.1–18), body weight (BW) of study aimed to develop a PK population model for piper- 11.9 kg (2.7–50), Pediatric Logistic Organ Dysfunction-2 acillin in order to optimize individual dosing regimens. (PELOD-2) severity score of 4 (0–16), and estimated -1 Methods All children aged B 18 years, weighing more glomerular filtration rate (eGFR) of 142 mL.min .1.73 - -2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Pharmacokinetics Springer Journals

Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
ISSN
0312-5963
eISSN
1179-1926
D.O.I.
10.1007/s40262-018-0682-1
Publisher site
See Article on Publisher Site

Abstract

Clin Pharmacokinet https://doi.org/10.1007/s40262-018-0682-1 ORIGINAL RESEARCH ARTICLE Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance 1,2 2,3 1,2 4 • • • • Agathe Be ´ranger Sihem Benaboud Saı ¨k Urien Florence Moulin 5 4 3 4 3 • • • • • Emmanuelle Bille Fabrice Lesage Yi Zheng Mathieu Genuini Ine `s Gana 4 2,3 1,2,3 2,4 • ´ • ´ • Sylvain Renolleau Deborah Hirt Jean-Marc Treluyer Mehdi Oualha Springer International Publishing AG, part of Springer Nature 2018 Abstract optimize dosing regimens in order to attain two PK targets: Background Critically ill children frequently display 50% fT and 100% fT . [MIC [MIC observed alterations of pharmacokinetic (PK) parameters, Results We included 50 children with a median (range) leading to a reduction in b-lactam concentrations. This postnatal age of 2.3 years (0.1–18), body weight (BW) of study aimed to develop a PK population model for piper- 11.9 kg (2.7–50), Pediatric Logistic Organ Dysfunction-2 acillin in order to optimize individual dosing regimens. (PELOD-2) severity score of 4 (0–16), and estimated -1 Methods All children aged B 18 years, weighing more glomerular filtration rate (eGFR) of 142 mL.min .1.73 - -2

Journal

Clinical PharmacokineticsSpringer Journals

Published: Jun 4, 2018

References

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