Clin Pharmacokinet https://doi.org/10.1007/s40262-018-0682-1 ORIGINAL RESEARCH ARTICLE Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance 1,2 2,3 1,2 4 • • • • Agathe Be ´ranger Sihem Benaboud Saı ¨k Urien Florence Moulin 5 4 3 4 3 • • • • • Emmanuelle Bille Fabrice Lesage Yi Zheng Mathieu Genuini Ine `s Gana 4 2,3 1,2,3 2,4 • ´ • ´ • Sylvain Renolleau Deborah Hirt Jean-Marc Treluyer Mehdi Oualha Springer International Publishing AG, part of Springer Nature 2018 Abstract optimize dosing regimens in order to attain two PK targets: Background Critically ill children frequently display 50% fT and 100% fT . [MIC [MIC observed alterations of pharmacokinetic (PK) parameters, Results We included 50 children with a median (range) leading to a reduction in b-lactam concentrations. This postnatal age of 2.3 years (0.1–18), body weight (BW) of study aimed to develop a PK population model for piper- 11.9 kg (2.7–50), Pediatric Logistic Organ Dysfunction-2 acillin in order to optimize individual dosing regimens. (PELOD-2) severity score of 4 (0–16), and estimated -1 Methods All children aged B 18 years, weighing more glomerular ﬁltration rate (eGFR) of 142 mL.min .1.73 - -2
Clinical Pharmacokinetics – Springer Journals
Published: Jun 4, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera