Physiology of EAG K+ Channels

Physiology of EAG K+ Channels J. Membrane Biol. 182, 1–15 (2001) The Journal of DOI: 10.1007/s00232-001-0031-3 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review C.K. Bauer, J.R. Schwarz Abteilung fu ¨ r Angewandte Physiologie, Institut fu ¨ r Physiologie, Universita ¨tsklinikum Hamburg-Eppendorf, D-20246 Hamburg, Germany Received: 24 July 2000/Revised: 25 October 2000 Introduction tramers formed by the assembly of four subunits, each consisting of six putative transmembrane domains with the S4 domain serving as the main voltage sensor (Fig. K channels form a large and diverse group of distinct 1A). EAG channels contain a Per-Arnt-Sim (PAS) do- ion channel families involved in a broad range of physi- ological functions (Pongs, 1992; Chandy & Gutman, main in the N-terminus (Morais Cabral et al., 1998), a characteristic signature sequence (GFGN) in the P re- 1995). This review concentrates on the description of the physiological role of members of the EAG family of gion, and a cyclic nucleotide binding domain (cNBD) voltage-gated K channels (in the following, EAG means within the C-terminus (Fig. 1A). belonging to the EAG K channel family). The eag (ether-a ´ -go-go) locus of Drosophila melanogaster was the first identified EAG gene cloned by chromosomal Identification of Endogenous EAG Channels analysis The Journal of Membrane Biology Springer Journals

Physiology of EAG K+ Channels

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Copyright © Inc. by 2001 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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