Physical performance across the thyroid function values within the normal range in adult and older persons

Physical performance across the thyroid function values within the normal range in adult and... Background Thyroid hormone variation may be correlated with adverse health outcomes, even within the normal reference range in euthyroid individuals. Aims To determine the association between plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels and physical performance score in middle age and older adults who had levels of all three hor- mones in the normal range. Methods In this community-based, cross-sectional study, euthyroid participants of the Invecchiare in Chianti study, aged 23–102 years (N = 1060), were considered. Physical performance was evaluated by the Summary Physical Performance Battery (SPPB) score. Plasma TSH, FT3, and FT4 levels were predictors, and SPPB score was the outcome. Results At the univariate analyses, TSH, FT4, and FT3 were not significantly associated with SPPB score in young individu- als, whereas, in older participants, SBBP score was positively (P < 0.001) associated with FT3, and negatively associated with both TSH (P < 0.02) and FT4 (P < 0.001). After adjusting for multiple confounders, FT3 remained significantly associated with SPPB (beta ± SE, 0.35 ± 0.17, P = 0.04), but FT4 and TSH were not. Results did not change when all the three hormones FT3, FT4, and TSH were simultaneously considered in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Aging Clinical and Experimental Research Springer Journals

Physical performance across the thyroid function values within the normal range in adult and older persons

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Geriatrics/Gerontology
eISSN
1720-8319
D.O.I.
10.1007/s40520-018-0975-0
Publisher site
See Article on Publisher Site

Abstract

Background Thyroid hormone variation may be correlated with adverse health outcomes, even within the normal reference range in euthyroid individuals. Aims To determine the association between plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels and physical performance score in middle age and older adults who had levels of all three hor- mones in the normal range. Methods In this community-based, cross-sectional study, euthyroid participants of the Invecchiare in Chianti study, aged 23–102 years (N = 1060), were considered. Physical performance was evaluated by the Summary Physical Performance Battery (SPPB) score. Plasma TSH, FT3, and FT4 levels were predictors, and SPPB score was the outcome. Results At the univariate analyses, TSH, FT4, and FT3 were not significantly associated with SPPB score in young individu- als, whereas, in older participants, SBBP score was positively (P < 0.001) associated with FT3, and negatively associated with both TSH (P < 0.02) and FT4 (P < 0.001). After adjusting for multiple confounders, FT3 remained significantly associated with SPPB (beta ± SE, 0.35 ± 0.17, P = 0.04), but FT4 and TSH were not. Results did not change when all the three hormones FT3, FT4, and TSH were simultaneously considered in the

Journal

Aging Clinical and Experimental ResearchSpringer Journals

Published: May 29, 2018

References

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